NEW ACTIVE MARINE ALKALOIDS

Title:

NEW ACTIVE MARINE ALKALOIDS

Document Type and Number:

WIPO Patent Application WO2001019824

Kind Code:

A3

Abstract:

New antitumour alkaloids of general formula (I) where R<1> is hydrogen, alkyl or acyl and R<2> is hydrogen or acyl, include jorumycin, where R<1> is hydrogen and R<2> is acetyl, extracted from the mollusc Jorunna funebris.

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Inventors:

CIMINO GUIDO (IT)
FONTANA ANGELO (IT)
GARCIA GRAVALOS DOLORES (ES)
WAHIDULLA SOLIMABI (IN)
NAIK CHANDRAKANT GOVIND (IN)

Application Number:

PCT/GB2000/003489

Publication Date:

September 27, 2001

Filing Date:

September 11, 2000

Export Citation:

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Assignee:

INST BIOMAR SA (ES)
RUFFLES GRAHAM KEITH (GB)
CIMINO GUIDO (IT)
FONTANA ANGELO (IT)
GARCIA GRAVALOS DOLORES (ES)
WAHIDULLA SOLIMABI (IN)
NAIK CHANDRAKANT GOVIND (IN)

International Classes:

A61K31/4995; A61K35/56; A61P1/00; A61P11/00; A61P17/00; A61P35/00; A61P35/02; C07D471/18; (IPC1-7): C07D471/18; A61K31/4995; A61P35/00

Foreign References:

US5023184A

1991-06-11

Other References:

HE, HAI YIN ET AL: "Renieramycins E and F from the sponge Reniera sp.: reassignment of the stereochemistry of the renieramycins", J. ORG. CHEM. (1989), 54(24), 5822-4, XP002162279
FONTANA, A. ET AL: "A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris", TETRAHEDRON (2000), 56(37), 7305-7308, XP002162280

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