Title:
NEW BENZIMIDAZOLE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2009/086731
Kind Code:
A1
Abstract:
New benzimidazole compounds of the following formula (I) which have activities
of inhibiting gastric acid secretion, resistingHelicobacter pylori
(Hp) and treating gastric cancer, wherein A, B, L, R1 and n are defined
as claim 1. The compounds have two functional groups of benzimidazole,which
may combine with the cysteine residues in the H+, K+-ATP
enzyme monomer or oligomer to inhibit the activity of H+, K+-ATP
enzyme after being activated by gastric acid in vivo. The compounds are
selective inhibitor of Hp.
Inventors:
CHENG MAOSHENG (CN)
WANG QINGHE (CN)
YANG YANHUI (CN)
NIE HAN (CN)
LI YUNWEI (CN)
WANG QINGHE (CN)
YANG YANHUI (CN)
NIE HAN (CN)
LI YUNWEI (CN)
Application Number:
PCT/CN2008/001977
Publication Date:
July 16, 2009
Filing Date:
December 05, 2008
Export Citation:
Assignee:
UNIV SHENYANG PHARMACEUTICAL (CN)
CHENG MAOSHENG (CN)
WANG QINGHE (CN)
YANG YANHUI (CN)
NIE HAN (CN)
LI YUNWEI (CN)
CHENG MAOSHENG (CN)
WANG QINGHE (CN)
YANG YANHUI (CN)
NIE HAN (CN)
LI YUNWEI (CN)
International Classes:
C07D401/12; A61K31/443; A61P1/04; A61P35/00
Foreign References:
| CN1369491A | 2002-09-18 | |||
| EP0005129A1 | 1979-10-31 |
Other References:
YANG, YAN HUI ET AL.: "Synthesis, Biological Evaluation, and Modeling of Dimeric PPI Analogues as Novel DNA Minor Groove Binders.", MOLECULES., vol. 13, no. 5, 2008, pages 1179 - 1188
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD (Bldg. BTsinghua Tongfang Hi-Tech Plaza,No.1, Wangzhuang Rd.,Haidian District, Beijing 3, CN)
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