Title:
A NEW POLYPEPTIDE-HUMAN L1 FACTOR ORF2 REVERSE TRANSCRIPTION-RELATED PROTEIN 13 AND THE POLYNUCLEOTIDE ENCODING IT
Document Type and Number:
WIPO Patent Application WO/2002/012324
Kind Code:
A1
Abstract:
The present invention disclose a new polypeptide-human L1 factor ORF2 reverse transcription-related protein 13, the polynucleotide encoding it and a method producing the polypeptide by recombinant DNA technology. The present invention further disclose a method using the polynucleotide to treat various disorders, e.g. malignant neoplasm, hematopathy, developmental disorder, HIV infection and immunological disease and various inflammation etc. The present invention also disclose an antagonist of the polypeptide and its therapeutic use. The present invention further disclose the use of the polynucleotide encoding the new human L1 factor ORF2 reverse transcription-related protein 13.
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Inventors:
MAO YUMIN (CN)
XIE YI (CN)
XIE YI (CN)
Application Number:
PCT/CN2001/000980
Publication Date:
February 14, 2002
Filing Date:
June 18, 2001
Export Citation:
Assignee:
BIOWINDOW GENE DEV INC (CN)
MAO YUMIN (CN)
XIE YI (CN)
MAO YUMIN (CN)
XIE YI (CN)
International Classes:
A61P35/00; A61P37/00; C07K14/47; C12N15/12; A61K38/00; (IPC1-7): C07K14/47; A61K38/17; A61P35/00; A61P37/00; C07K14/435; C12N15/12; C12N15/63; C12N15/85
Other References:
SHELL B.E. ET AL.: "Two subfamilies of murine retrotransposon ETn sequences", GENE, vol. 86, no. 2, 1990, pages 269 - 274
SCOTT A.F. ET AL.: "Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence", GENOMICS, vol. 1, no. 2, 1987, pages 113 - 125
DATABASE PROTEIN [online] 26 August 1999 (1999-08-26), Database accession no. S65824
HATTORI M. ET AL.: "L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein", NATURE, vol. 321, no. 6070, 1986, pages 625 - 628
ANDO T. ET AL.: "A one-tube method of reverse transcription-PCR to efficiently amplify a 3-kilobase region from the RNA polymerase gene to the poly(A) tail of small round-structured viruses (Norwalk-like-viruses)", J. CLIN. MICROBIOL., vol. 35, no. 3, 1997, pages 570 - 577
SANTOS F.R. ET AL.: "A polymorphic L1 retroposon insertion in the centromere of the human Y chromosome", HUM. MOL. GENET., vol. 9, no. 3, 2000, pages 421 - 430
SASSAMAN D. ET AL.: "Many human L1 elements are capable of retrotransposition", NATURE GENET., vol. 16, no. 1, 1997, pages 37 - 43
SCOTT A.F. ET AL.: "Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence", GENOMICS, vol. 1, no. 2, 1987, pages 113 - 125
DATABASE PROTEIN [online] 26 August 1999 (1999-08-26), Database accession no. S65824
HATTORI M. ET AL.: "L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein", NATURE, vol. 321, no. 6070, 1986, pages 625 - 628
ANDO T. ET AL.: "A one-tube method of reverse transcription-PCR to efficiently amplify a 3-kilobase region from the RNA polymerase gene to the poly(A) tail of small round-structured viruses (Norwalk-like-viruses)", J. CLIN. MICROBIOL., vol. 35, no. 3, 1997, pages 570 - 577
SANTOS F.R. ET AL.: "A polymorphic L1 retroposon insertion in the centromere of the human Y chromosome", HUM. MOL. GENET., vol. 9, no. 3, 2000, pages 421 - 430
SASSAMAN D. ET AL.: "Many human L1 elements are capable of retrotransposition", NATURE GENET., vol. 16, no. 1, 1997, pages 37 - 43
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