Title:
NF-κB ACTIVATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2007/145253
Kind Code:
A1
Abstract:
The object is to provide a highly safe NF-κB activation inhibitor at a low cost which can be used for the prevention or treatment of a disease associated with the activation of NF-κB such as an inflammation or type-2 diabetes. Specifically, the NF-κB activation inhibitor comprises a compound represented by the chemical structural formula depicted in Chemical Formula 1 [wherein R1 represents a hydroxy group; R2 represents a hydroxy group, a methoxy group or an alkoxy group; and R3 represents an ester comprising a triterpene or a salt thereof] or a salt of the compound as an active ingredient. Arepresentative example of the compound is a hydroxycinnamic acid derivative triterpene alcohol ester.
Inventors:
USHIO HIDEKI (JP)
NAGASAKA REIKO (JP)
OHHARA KAZUYUKI (JP)
OZAKI HIROSHI (JP)
HORI MASATOSHI (JP)
NAGASAKA REIKO (JP)
OHHARA KAZUYUKI (JP)
OZAKI HIROSHI (JP)
HORI MASATOSHI (JP)
Application Number:
PCT/JP2007/061917
Publication Date:
December 21, 2007
Filing Date:
June 13, 2007
Export Citation:
Assignee:
TOKYO UNIVERSITY OF MARINE SCI (JP)
UNIV TOKYO (JP)
USHIO HIDEKI (JP)
NAGASAKA REIKO (JP)
OHHARA KAZUYUKI (JP)
OZAKI HIROSHI (JP)
HORI MASATOSHI (JP)
UNIV TOKYO (JP)
USHIO HIDEKI (JP)
NAGASAKA REIKO (JP)
OHHARA KAZUYUKI (JP)
OZAKI HIROSHI (JP)
HORI MASATOSHI (JP)
International Classes:
A61K31/575; A61K31/56; A61P1/04; A61P3/10; A61P29/00; A61P43/00; C07J9/00; C07J53/00
Foreign References:
| JP2005068132A | 2005-03-17 | |||
| JPS60258198A | 1985-12-20 |
Other References:
KASHIWADA A.: "Ferulic Acid Yudotai ni yoru Insulin Bunpitsu Sokushin Koka", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 81 SHUNKI NENKAI 2002 NEN KOEN YOKOSHU II, 11 March 2002 (2002-03-11), pages 1387, XP003020947
YASUKAWA K. ET AL.: "Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin", BIOL. PHARM. BULL., vol. 21, no. 10, 1998, pages 1072 - 1076, XP003020948
LIU I.M.: "Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats", BR. J. PHARMACOL., vol. 129, no. 4, 2000, pages 631 - 636, XP003020949
TERADA S.: "Anti-inflammatory effects of gamma-oryzanol", NATURAL MEDICINES, vol. 57, no. 3, 2003, pages 95 - 99, XP003020950
UKIYA M. ET AL.: "Komenukayu kara no Sterol Ferulic Acid Ester no Kozo to Keonshosei ni Tsuite", ABSTRACTS OF THE MEETING ON OIL CHEMISTRY (DAI 37 KAI), 1998, XP003020951
YASUKAWA K. ET AL.: "Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin", BIOL. PHARM. BULL., vol. 21, no. 10, 1998, pages 1072 - 1076, XP003020948
LIU I.M.: "Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats", BR. J. PHARMACOL., vol. 129, no. 4, 2000, pages 631 - 636, XP003020949
TERADA S.: "Anti-inflammatory effects of gamma-oryzanol", NATURAL MEDICINES, vol. 57, no. 3, 2003, pages 95 - 99, XP003020950
UKIYA M. ET AL.: "Komenukayu kara no Sterol Ferulic Acid Ester no Kozo to Keonshosei ni Tsuite", ABSTRACTS OF THE MEETING ON OIL CHEMISTRY (DAI 37 KAI), 1998, XP003020951
Attorney, Agent or Firm:
KUBOTA, Noriaki (Thokenshimazuyamaminamihaitsu25-19, Higashigotanda 1-chome,Shinagawa-k, Tokyo 22, JP)
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