Title:
NIMR COMPOSITIONS AND THEIR METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2001070776
Kind Code:
A3
Abstract:
Mar regulated (NIMR) genes and polypeptides are described. In addition, screening assays to identify agents that modulate NIMR activity are provided.
Inventors:
LEVY STUART B
BARBOSA TERESA M
ALEKSHUN MICHAEL N
BARBOSA TERESA M
ALEKSHUN MICHAEL N
Application Number:
PCT/US2001/007478
Publication Date:
January 09, 2003
Filing Date:
March 08, 2001
Export Citation:
Assignee:
TUFTS COLLEGE (US)
International Classes:
G01N33/50; A61K38/00; A61K39/00; A61K45/00; A61K48/00; A61P31/04; C07K14/195; C07K14/245; C12N1/20; C12N15/09; C12N15/31; C12Q1/02; C12Q1/18; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): G01N33/68; C12Q1/68; A61K39/108; A61K48/00; C07K14/245; C12N15/31
Foreign References:
| US5766924A | 1998-06-16 |
Other References:
LI HONGSHAN ET AL: "The periplasmic murein peptide-binding protein MppA is a negative regulator of multiple antibiotic resistance in Escherichia coli.", JOURNAL OF BACTERIOLOGY, vol. 181, no. 16, August 1999 (1999-08-01), pages 4842 - 4847, XP002194668, ISSN: 0021-9193
MARTIN ROBERT G ET AL: "Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli.", JOURNAL OF BACTERIOLOGY, vol. 178, no. 8, 1996, pages 2216 - 2223, XP002194669, ISSN: 0021-9193
AONO RIKIZO ET AL: "Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 4, February 1998 (1998-02-01), pages 938 - 944, XP002194670, ISSN: 0021-9193
BARBOSA TERESA M ET AL: "Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA.", JOURNAL OF BACTERIOLOGY, vol. 182, no. 12, June 2000 (2000-06-01), pages 3467 - 3474, XP002194671, ISSN: 0021-9193
BLATTNER FREDERICK R ET AL: "The complete genome sequence of Escherichia coli K-12.", SCIENCE (WASHINGTON D C), vol. 277, no. 5331, 1997, pages 1453 - 1462, XP002069950, ISSN: 0036-8075
DATABASE NCBI 1 December 2000 (2000-12-01), "Putative alpha helix chain of E. coli K12 (YaiN)", XP002194672
MARTIN ROBERT G ET AL: "Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli.", JOURNAL OF BACTERIOLOGY, vol. 178, no. 8, 1996, pages 2216 - 2223, XP002194669, ISSN: 0021-9193
AONO RIKIZO ET AL: "Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 4, February 1998 (1998-02-01), pages 938 - 944, XP002194670, ISSN: 0021-9193
BARBOSA TERESA M ET AL: "Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA.", JOURNAL OF BACTERIOLOGY, vol. 182, no. 12, June 2000 (2000-06-01), pages 3467 - 3474, XP002194671, ISSN: 0021-9193
BLATTNER FREDERICK R ET AL: "The complete genome sequence of Escherichia coli K-12.", SCIENCE (WASHINGTON D C), vol. 277, no. 5331, 1997, pages 1453 - 1462, XP002069950, ISSN: 0036-8075
DATABASE NCBI 1 December 2000 (2000-12-01), "Putative alpha helix chain of E. coli K12 (YaiN)", XP002194672
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