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Title:
NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS
Document Type and Number:
WIPO Patent Application WO2002017880
Kind Code:
A3
Abstract:
Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.

Inventors:
HILL-WEST JENNIFER L (US)
MASTERS KRISTYN SIMCHA (US)
Application Number:
US0127414W
Publication Date:
March 27, 2003
Filing Date:
September 04, 2001
Export Citation:
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Assignee:
RICE UNIVERSITY
HILL-WEST, JENNIFER, L.
MASTERS, KRISTYN, SIMCHA
International Classes:
A61K45/00; A61K45/06; A61K47/48; A61P9/08; A61P9/10; A61P11/06; A61P15/10; A61P17/02; A61P19/02; C08F299/02; C08G65/333; C08G65/334; (IPC1-7): A61K479/48
Domestic Patent References:
WO1996015797A11996-05-30
WO2001015738A22001-03-08
Foreign References:
US5632981A1997-05-27
US5849839A1998-12-15
Other References:
BOHL K S ET AL: "Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation.", BIOMATERIALS. ENGLAND NOV 2000, vol. 21, no. 22, November 2000 (2000-11-01), pages 2273 - 2278, XP002224666, ISSN: 0142-9612
BOHL K ET AL: "NITRIC OXIDE PRODUCING MATERIALS: A POTENTIAL THERAPY FOR THROMBOSIS AND RESTENOSIS", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, XX, XX, 1999, pages 56 - 57, XP001009872, ISSN: 1022-0178
BOHL KRISTYN S ET AL: "Nitric oxide-releasing hydrogels for the prevention of thrombosis and restenosis.", CIRCULATION, vol. 102, no. 18 Supplement, 31 October 2000 (2000-10-31), Abstracts from Scientific Sessions 2000;New Orleans, Louisiana, USA; November 12-15, 2000, pages II.734, XP008011370, ISSN: 0009-7322
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