Title:
NITROGEN-CONTAINING CONDENSED RING COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT
Document Type and Number:
WIPO Patent Application WO/2018/021447
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound having D3 receptor antagonistic effect. Provided are the following: a compound represented by formula (I) (in the formula, ring A is a heterocyclic ring, X1 groups are each independently CR4aR4b, X2 groups are each independently CR4cR4d, Y1 and Y2 are each independently a carbon atom or a nitrogen atom, L is -N(R6)-C(=O)- or the like, W is a ring-like group or the like, R2 and R3 are each independently a substituted or unsubstituted alkyl group or the like, R1a, R1b, R4a to R4d and R6 are each independently a hydrogen atom or the like, p is 1 or 2, q is an integer between 1 and 3, n is an integer between 1 and 4, and s is an integer between 0 and 4); or a pharmaceutically acceptable salt thereof.
Inventors:
TOBINAGA HIROYUKI (JP)
MASUDA KOJI (JP)
KASUYA SATOSHI (JP)
INAGAKI MASANAO (JP)
YONEHARA MITSUHIRO (JP)
MASUDA MANAMI (JP)
MASUDA KOJI (JP)
KASUYA SATOSHI (JP)
INAGAKI MASANAO (JP)
YONEHARA MITSUHIRO (JP)
MASUDA MANAMI (JP)
Application Number:
PCT/JP2017/027141
Publication Date:
February 01, 2018
Filing Date:
July 27, 2017
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D471/04; A61K31/437; A61K31/4709; A61K31/4985; A61K31/519; A61K31/5377; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P39/02; A61P43/00; C07D487/04; C07D498/04; C07D513/04; C07D513/08
Domestic Patent References:
| WO2017021920A1 | 2017-02-09 |
Foreign References:
| JPH09506346A | 1997-06-24 | |||
| JP2008537741A | 2008-09-25 | |||
| JP2012509856A | 2012-04-26 | |||
| JP2010534665A | 2010-11-11 | |||
| JP2008502581A | 2008-01-31 | |||
| JP2000517301A | 2000-12-26 | |||
| JP2001522366A | 2001-11-13 | |||
| JP2002528437A | 2002-09-03 | |||
| JP2002527433A | 2002-08-27 | |||
| JP2002527432A | 2002-08-27 |
Other References:
MACH, U.R. ET AL.: "Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands", CHEMBIOCHEM, vol. 5, no. 4, 2004, pages 508 - 518, XP002650943, DOI: doi:10.1002/cbic.200300784
See also references of EP 3495363A4
See also references of EP 3495363A4
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
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