Title:
NITROGEN-CONTAINING HETEROARYL COMPOUND, AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/069973
Kind Code:
A1
Abstract:
The present invention provides a compound having GLUT9 inhibitory activity. The present invention provides a compound of formula (I) or a phamacologically acceptable salt thereof. (The symbols in the formula are as defined in the specification.)
Inventors:
NAGAMORI HIRONOBU (JP)
NISHIMARU TATSUYA (JP)
TAKAGI MASAKI (JP)
MITANI IKUO (JP)
NAKAGAWA YUICHI (JP)
NISHIMARU TATSUYA (JP)
TAKAGI MASAKI (JP)
MITANI IKUO (JP)
NAKAGAWA YUICHI (JP)
Application Number:
PCT/JP2018/037007
Publication Date:
April 11, 2019
Filing Date:
October 03, 2018
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D213/55; A61K31/4418; A61K31/4433; A61K31/472; A61K31/4965; A61K31/497; A61P19/06; A61P43/00; C07D213/61; C07D217/16; C07D241/12; C07D405/04
Domestic Patent References:
| WO2011119866A1 | 2011-09-29 | |||
| WO2008126901A1 | 2008-10-23 |
Foreign References:
| JPH11514008A | 1999-11-30 | |||
| JP2008536950A | 2008-09-11 | |||
| JP2007176933A | 2007-07-12 | |||
| CN104306363A | 2015-01-28 |
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WU, F. ET AL.: "3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 2016, pages 253 - 263, XP055440785
GENOMICS, vol. 66, no. 2, 1 June 2000 (2000-06-01), pages 217 - 20
PLOS GENET., vol. 3, no. ll, November 2007 (2007-11-01), pages el94
NAT GENET., vol. 40, no. 4, April 2008 (2008-04-01), pages 437 - 42
J BIOL CHEM., vol. 283, no. 40, 3 October 2008 (2008-10-03), pages 26834 - 8
ADMET & DMPK, vol. 5, no. 2, 2017, pages 59 - 74
AM J HUM GENET., vol. 83, no. 6, December 2008 (2008-12-01), pages 744 - 51
NEPHROL DIAL TRANSPLANT., vol. 27, no. 3, March 2012 (2012-03-01), pages 1035 - 41
"Guideline Revision Committee", 2010, JAPANESE SOCIETY OF GOUT AND NUCLEIC ACID METABOLISM, article "Japanese guideline for the management of hyperuricemia and gout"
AM J KIDNEY DIS., vol. 44, no. 4, October 2004 (2004-10-01), pages 642 - 50
J AM SOC NEPHROL., vol. 19, no. 12, December 2008 (2008-12-01), pages 2407 - 13
PLOS ONE, vol. 9, no. 6, 24 June 2014 (2014-06-24), pages elO0801
AM J KIDNEY DIS., vol. 66, no. 6, December 2015 (2015-12-01), pages 945 - 50
CLIN J AM SOC NEPHROL., vol. 9, no. 6, 6 June 2014 (2014-06-06), pages 1059 - 65
HYPERTENSION, vol. 48, no. 6, December 2006 (2006-12-01), pages 1031 - 6
ANN RHEUM DIS., vol. 72, no. 8, August 2013 (2013-08-01), pages 1321 - 7
JAMA, vol. 300, no. 8, 27 August 2008 (2008-08-27), pages 924 - 32
PLOS ONE, vol. 8, no. 2, 2013, pages e56864
MOL CELL ENDOCRINOL., vol. 375, no. 1-2, 15 August 2013 (2013-08-15), pages 89 - 96
BIOCHEM BIOPHYS RES COMMUN., vol. 447, no. 4, 16 May 2014 (2014-05-16), pages 707 - 14
"National Health and Nutrition Examination Survey", JAMA, vol. 283, no. 18, 10 May 2000 (2000-05-10), pages 2404 - 10
CORON ARTERY DIS., vol. 25, no. 4, June 2014 (2014-06-01), pages 343 - 8
INT J CARDIOL., vol. 151, no. 2, 1 September 2011 (2011-09-01), pages 143 - 7
HYPERTENS RES., vol. 37, no. 8, August 2014 (2014-08-01), pages 785 - 9
BR J RHEUMATOL., vol. 33, no. 8, August 1994 (1994-08-01), pages 731 - 4
THER RES, vol. 33, 2012, pages 1397 - 1405
J CLIN ENDOCRINOL METAB., vol. 100, no. 11, November 2015 (2015-11-01), pages 4198 - 207
AM J DERMATOPATHOL., vol. 3, no. 4, 1981, pages 397 - 404
ARCH DERMATOL., vol. 144, no. 11, November 2008 (2008-11-01), pages 1518 - 9
BMJ, vol. 347, 15 October 2013 (2013-10-15), pages f5961
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
STAHL ET AL.: "Handbook of Pharmaceutical Salt: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
GOUT AND NUCLEIC ACID METABOLISM, vol. 37, no. 2, 2013, pages 93 - 101
See also references of EP 3693358A4
GENOMICS, vol. 66, no. 2, 1 June 2000 (2000-06-01), pages 217 - 20
PLOS GENET., vol. 3, no. ll, November 2007 (2007-11-01), pages el94
NAT GENET., vol. 40, no. 4, April 2008 (2008-04-01), pages 437 - 42
J BIOL CHEM., vol. 283, no. 40, 3 October 2008 (2008-10-03), pages 26834 - 8
ADMET & DMPK, vol. 5, no. 2, 2017, pages 59 - 74
AM J HUM GENET., vol. 83, no. 6, December 2008 (2008-12-01), pages 744 - 51
NEPHROL DIAL TRANSPLANT., vol. 27, no. 3, March 2012 (2012-03-01), pages 1035 - 41
"Guideline Revision Committee", 2010, JAPANESE SOCIETY OF GOUT AND NUCLEIC ACID METABOLISM, article "Japanese guideline for the management of hyperuricemia and gout"
AM J KIDNEY DIS., vol. 44, no. 4, October 2004 (2004-10-01), pages 642 - 50
J AM SOC NEPHROL., vol. 19, no. 12, December 2008 (2008-12-01), pages 2407 - 13
PLOS ONE, vol. 9, no. 6, 24 June 2014 (2014-06-24), pages elO0801
AM J KIDNEY DIS., vol. 66, no. 6, December 2015 (2015-12-01), pages 945 - 50
CLIN J AM SOC NEPHROL., vol. 9, no. 6, 6 June 2014 (2014-06-06), pages 1059 - 65
HYPERTENSION, vol. 48, no. 6, December 2006 (2006-12-01), pages 1031 - 6
ANN RHEUM DIS., vol. 72, no. 8, August 2013 (2013-08-01), pages 1321 - 7
JAMA, vol. 300, no. 8, 27 August 2008 (2008-08-27), pages 924 - 32
PLOS ONE, vol. 8, no. 2, 2013, pages e56864
MOL CELL ENDOCRINOL., vol. 375, no. 1-2, 15 August 2013 (2013-08-15), pages 89 - 96
BIOCHEM BIOPHYS RES COMMUN., vol. 447, no. 4, 16 May 2014 (2014-05-16), pages 707 - 14
"National Health and Nutrition Examination Survey", JAMA, vol. 283, no. 18, 10 May 2000 (2000-05-10), pages 2404 - 10
CORON ARTERY DIS., vol. 25, no. 4, June 2014 (2014-06-01), pages 343 - 8
INT J CARDIOL., vol. 151, no. 2, 1 September 2011 (2011-09-01), pages 143 - 7
HYPERTENS RES., vol. 37, no. 8, August 2014 (2014-08-01), pages 785 - 9
BR J RHEUMATOL., vol. 33, no. 8, August 1994 (1994-08-01), pages 731 - 4
THER RES, vol. 33, 2012, pages 1397 - 1405
J CLIN ENDOCRINOL METAB., vol. 100, no. 11, November 2015 (2015-11-01), pages 4198 - 207
AM J DERMATOPATHOL., vol. 3, no. 4, 1981, pages 397 - 404
ARCH DERMATOL., vol. 144, no. 11, November 2008 (2008-11-01), pages 1518 - 9
BMJ, vol. 347, 15 October 2013 (2013-10-15), pages f5961
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
STAHL ET AL.: "Handbook of Pharmaceutical Salt: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
GOUT AND NUCLEIC ACID METABOLISM, vol. 37, no. 2, 2013, pages 93 - 101
See also references of EP 3693358A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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