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Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041589
Kind Code:
A1
Abstract:
Disclosed are a nitrogen-containing heterocyclic compound, a preparation method therefor, an intermediate thereof, and use thereof. Specifically, the present invention provides a nitrogen-containing heterocyclic compound as represented by formula (I), a solvate thereof, a pharmaceutically acceptable salt thereof, or a solvate of a pharmaceutically acceptable salt thereof. A metabolite of the nitrogen-containing heterocyclic compound as represented by formula (I) has the activity of inhibiting the proliferation of Ba/F3 KRAS-G12D cells, AGS cells and Ba/F3 KRAS-G12V cells expressing KRAS G12D and/or KRAS G12V mutant proteins. The nitrogen-containing heterocyclic compound has better pharmacokinetic properties. The nitrogen-containing heterocyclic compound is expected to treat and/or prevent various diseases mediated by KRAS G12D and/or KRAS G12V.

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Inventors:
LUO HUIBING (CN)
WANG JIAPO (CN)
JIANG JIAJUN (CN)
LI QING (CN)
Application Number:
PCT/CN2023/114576
Publication Date:
February 29, 2024
Filing Date:
August 24, 2023
Export Citation:
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Assignee:
SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D471/04; A61K31/435; A61K31/4375; A61K31/517; A61K31/519; A61P35/00; C07D471/02; C07D487/04; C07D519/00
Domestic Patent References:
WO2023098425A12023-06-08
WO2023134465A12023-07-20
WO2022184178A12022-09-09
WO2022214102A12022-10-13
WO2023098426A12023-06-08
WO2022015375A12022-01-20
WO2022170999A12022-08-18
Foreign References:
CN115785124A2023-03-14
CN116284055A2023-06-23
Other References:
JI XIANG, LI YAN, KONG XIANQI, CHEN DAWEI, LU JIASHENG: "Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS G12D Mutation", ACS OMEGA, ACS PUBLICATIONS, US, vol. 8, no. 7, 21 February 2023 (2023-02-21), US , pages 7211 - 7221, XP093143519, ISSN: 2470-1343, DOI: 10.1021/acsomega.3c00329
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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