Title:
NITROGENOUS CYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/053258
Kind Code:
A1
Abstract:
Novel compounds exhibiting excellent calcium antagonism, particularly neuroselective calcium antagonism, namely, compounds of the general formula (I), salts of the same, or hydrates of both wherein Ar is a group derived from an optionally substituted 5- to 14-membered aromatic ring, or the like; the ring A is one member selected from among piperazine, homopiperazine, piperidine and so on; the ring B is an optionally substituted C¿3-14? hydrocarbon ring or the like; E is a single bond, -CO-, or the like; X is a single bond, oxygen, or the like; R?1¿ is hydrogen, halogeno, hydroxyl, or the like; and D?1¿, D?2¿, W?1¿ and W?2¿ are each independently a single bond or optionally substituted C¿1-6? alkylene.
Inventors:
YAMAMOTO NOBORU (JP)
SUZUKI YUICHI (JP)
KIMURA MANAMI (JP)
NIIDOME TETSUHIRO (JP)
IIMURA YOICHI (JP)
TERAMOTO TETSUYUKI (US)
KANEDA YOSHIHISA (JP)
KANEKO TOSHIHIKO (JP)
KURUSU NOBUYUKI (JP)
SHINMYO DAISUKE (JP)
YOSHIKAWA YUKIE (JP)
HATAKEYAMA SHINJI (JP)
SUZUKI YUICHI (JP)
KIMURA MANAMI (JP)
NIIDOME TETSUHIRO (JP)
IIMURA YOICHI (JP)
TERAMOTO TETSUYUKI (US)
KANEDA YOSHIHISA (JP)
KANEKO TOSHIHIKO (JP)
KURUSU NOBUYUKI (JP)
SHINMYO DAISUKE (JP)
YOSHIKAWA YUKIE (JP)
HATAKEYAMA SHINJI (JP)
Application Number:
PCT/JP2001/000288
Publication Date:
July 26, 2001
Filing Date:
January 18, 2001
Export Citation:
Assignee:
EISAI CO LTD (JP)
YAMAMOTO NOBORU (JP)
SUZUKI YUICHI (JP)
KIMURA MANAMI (JP)
NIIDOME TETSUHIRO (JP)
IIMURA YOICHI (JP)
TERAMOTO TETSUYUKI (US)
KANEDA YOSHIHISA (JP)
KANEKO TOSHIHIKO (JP)
KURUSU NOBUYUKI (JP)
SHINMYO DAISUKE (JP)
YOSHIKAWA YUKIE (JP)
HATAKEYAMA SHINJI (JP)
YAMAMOTO NOBORU (JP)
SUZUKI YUICHI (JP)
KIMURA MANAMI (JP)
NIIDOME TETSUHIRO (JP)
IIMURA YOICHI (JP)
TERAMOTO TETSUYUKI (US)
KANEDA YOSHIHISA (JP)
KANEKO TOSHIHIKO (JP)
KURUSU NOBUYUKI (JP)
SHINMYO DAISUKE (JP)
YOSHIKAWA YUKIE (JP)
HATAKEYAMA SHINJI (JP)
International Classes:
A61K31/395; A61P9/10; C07D207/09; C07D207/14; C07D207/16; C07D207/337; C07D209/14; C07D209/42; C07D211/22; C07D211/26; C07D211/32; C07D211/34; C07D211/46; C07D211/58; C07D211/64; C07D213/36; C07D213/38; C07D213/57; C07D213/74; C07D215/06; C07D215/12; C07D215/227; C07D215/38; C07D217/04; C07D217/22; C07D235/14; C07D235/30; C07D241/04; C07D243/08; C07D261/08; C07D263/20; C07D263/32; C07D263/58; C07D271/06; C07D277/28; C07D277/42; C07D277/82; C07D295/14; C07D295/145; C07D295/185; C07D295/192; C07D295/215; C07D307/52; C07D307/54; C07D307/81; C07D319/20; C07D333/24; C07D333/28; C07D333/38; C07D333/60; C07D401/04; C07D401/06; C07D401/12; C07D403/04; C07D405/06; C07D409/00; C07D409/06; C07D409/12; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/08; C07D417/12; C07D471/10; C07D487/08; C07D207/32; C07D215/22; C07D235/10; (IPC1-7): C07D207/09; C07D295/14; C07D295/192; C07D307/81; C07D235/14; C07D209/14; C07D215/12; C07D213/38; C07D487/08; C07D471/10; C07D319/20; C07D401/04; C07D413/12
Domestic Patent References:
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| WO1991009015A1 | 1991-06-27 | |||
| WO1997026258A1 | 1997-07-24 | |||
| WO1996026196A2 | 1996-08-29 | |||
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Other References:
MOEHRLE HANS, PYCIOR MARTIN: "Symmetric Mannich compounds", ARCH. PHARM., vol. 328, no. 6, 1995, (WEINHEIM, GER.), pages 565 - 568, XP002937451
BUTORA GABRIEL ET AL.: "Some new analogs of verapamil and mepamil. Synthesis and basic pharmacological properties", COLLECT. CZECH. CHEM. COMMUN., vol. 57, no. 9, 1992, pages 1967 - 1981, XP002937452
CARCELLER ELENA ET AL.: "(Pyridylcyanomethyl)piperazines as orally active PAF antagonists", J. MED. CHEM., vol. 35, no. 22, 1992, pages 4118 - 4134, XP002937453
LAGUERRE M. ET AL.: "Calcium channel blockers. I. Replacement of the 3,4-dimethoxyphenylethyl group of verapamil", EUR. J. MED. CHEM., vol. 25, no. 4, 1990, pages 351 - 359, XP002937454
VARTANYAN R.S. ET AL.: "4-Anilides of 1-substituted 2,5-dimethylpiperidines: Synthesis and analgesic activity", KHIM.-FARM. ZH., vol. 23, no. 5, 1989, pages 562 - 565, XP002937455
LACHOWICZ JEAN E ET AL.: "SCH 57790: A novel M2 receptor selective antagonist", LIFE SCI., vol. 64, no. 6/7, 1999, pages 535 - 539, XP002937456
YEVICH JOSEPH P ET AL.: "Synthesis and biological characterization of .alpha.-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogs as potential atypical antiphychotic agents", J. MED. CHEM., vol. 35, no. 24, 1992, pages 4516 - 4525, XP002937457
See also references of EP 1254895A4
BUTORA GABRIEL ET AL.: "Some new analogs of verapamil and mepamil. Synthesis and basic pharmacological properties", COLLECT. CZECH. CHEM. COMMUN., vol. 57, no. 9, 1992, pages 1967 - 1981, XP002937452
CARCELLER ELENA ET AL.: "(Pyridylcyanomethyl)piperazines as orally active PAF antagonists", J. MED. CHEM., vol. 35, no. 22, 1992, pages 4118 - 4134, XP002937453
LAGUERRE M. ET AL.: "Calcium channel blockers. I. Replacement of the 3,4-dimethoxyphenylethyl group of verapamil", EUR. J. MED. CHEM., vol. 25, no. 4, 1990, pages 351 - 359, XP002937454
VARTANYAN R.S. ET AL.: "4-Anilides of 1-substituted 2,5-dimethylpiperidines: Synthesis and analgesic activity", KHIM.-FARM. ZH., vol. 23, no. 5, 1989, pages 562 - 565, XP002937455
LACHOWICZ JEAN E ET AL.: "SCH 57790: A novel M2 receptor selective antagonist", LIFE SCI., vol. 64, no. 6/7, 1999, pages 535 - 539, XP002937456
YEVICH JOSEPH P ET AL.: "Synthesis and biological characterization of .alpha.-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogs as potential atypical antiphychotic agents", J. MED. CHEM., vol. 35, no. 24, 1992, pages 4516 - 4525, XP002937457
See also references of EP 1254895A4
Attorney, Agent or Firm:
Furuya, Kaoru (2-17-8 Nihonbashi-Hamach, Chuo-ku Tokyo, JP)
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