Title:
NITRONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/013332
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof, useful as the remedies for nerve degeneration diseases such as neuropil degeneration diseases, wherein Ar is optionally substituted phenyl or an optionally substituted aromatic heterocyclic group; n is 0, 1 or 2; W is -CH�2?NH- or -CH=N(O)-; R?1�, R?2� and R?3� are each independently optionally substituted alkyl, carboxyl or alkoxycarbonyl, provided two of R?1�, R?2� and R?3� may form together with the carbon atoms to which they are bonded a cycloalkane ring, or R?1�, R?2� and R?3� may form together with the carbon atom to which they are bonded a bicycloalkane or tricycloalkane ring, with the cycloalkane, bicycloalkane and tricycloalkane rings being each optionally substituted; and R?4� and R?5� are each independently hydrogen or optionally substituted alkyl.
Inventors:
IKEDA KAZUHITO (JP)
TATSUNO TOHRU (JP)
OGO HIROKI (JP)
MASUMOTO SHUJI (JP)
FUJIBAYASHI TATSUYA (JP)
NAGATA RYU (JP)
TATSUNO TOHRU (JP)
OGO HIROKI (JP)
MASUMOTO SHUJI (JP)
FUJIBAYASHI TATSUYA (JP)
NAGATA RYU (JP)
Application Number:
PCT/JP1997/003377
Publication Date:
April 02, 1998
Filing Date:
September 22, 1997
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
IKEDA KAZUHITO (JP)
TATSUNO TOHRU (JP)
OGO HIROKI (JP)
MASUMOTO SHUJI (JP)
FUJIBAYASHI TATSUYA (JP)
NAGATA RYU (JP)
IKEDA KAZUHITO (JP)
TATSUNO TOHRU (JP)
OGO HIROKI (JP)
MASUMOTO SHUJI (JP)
FUJIBAYASHI TATSUYA (JP)
NAGATA RYU (JP)
International Classes:
C07C211/27; A61K31/137; A61K31/15; A61K31/357; A61K31/381; A61K31/40; A61K31/415; A61K31/4164; A61K31/4402; C07C215/08; C07C217/08; C07C219/06; C07C291/02; (IPC1-7): C07C211/27; A61K31/135; A61K31/15; A61K31/275; A61K31/335; A61K31/38; A61K31/40; A61K31/415; A61K31/44; C07C211/28; C07C255/58; C07C291/04; C07D207/335; C07D213/42; C07D231/12; C07D317/28; C07D333/20; C07D521/00
Domestic Patent References:
| WO1992022290A1 | 1992-12-23 | |||
| WO1995017876A2 | 1995-07-06 |
Foreign References:
| JPH09278652A | 1997-10-28 | |||
| JPH05505792A | 1993-08-26 | |||
| JPS4423322B1 | ||||
| JPS49135962A | 1974-12-27 |
Other References:
NEUROSCIENCE, 73(1), (1996), N. NAKAO et al., "Antioxidant Treatment Protects Striatal Neurons Against Excitotoxic Insults", pages 185-200.
BIOCHEM. BIOPHYS. RES. COMMUN., 221, (1996), TAHEREH TABATABIE et al., "In Vivo Trapping of Nitric Oxide in the Brain of Neonatal Rats Treated with the HIV-1 Envelope Protein gp 120: Protective Effects of Alpha-Phenyl-Tert-Butylnitrone", pages 386-390.
J. NEUROSCIENCE, 15(11), (1995), D.W. NEWELL et al., "Glutamate and Non-Glutamate Receptor Mediated Toxicity Caused by Oxygen and Glucose Deprivation in Organotypic Hippocampal Cultures", pages 7702-7711.
NEUROSCIENCE, 71(4), (1996), J.B. SCHULTZ et al., "Neuroprotective Strategies for Treatment of Lesions Produced by Mitochondrial Toxins: Implications for Neurodegenerative Diseases", pages 1043-1048.
J. AM. OPTOMETRIC ASSOC., 64(12), (1993), A.M. VAN DER HAGEN et al., "Free Radicals and Antioxidant Supplementation: A Review of Their Roles in Age-Related Macular Degeneration", pages 871-878.
LIEBIGS. ANN. CHEM., (5), (1990), SAMY B. SAID et al., "Synthesis of 2-Alkyl-3-Vinyloxaziridines as Potential Antitumor Agents", pages 461-464.
CHEMICAL ABSTRACTS, Vol. 55, (1961), Abstract No. 23559i.
See also references of EP 0945426A4
BIOCHEM. BIOPHYS. RES. COMMUN., 221, (1996), TAHEREH TABATABIE et al., "In Vivo Trapping of Nitric Oxide in the Brain of Neonatal Rats Treated with the HIV-1 Envelope Protein gp 120: Protective Effects of Alpha-Phenyl-Tert-Butylnitrone", pages 386-390.
J. NEUROSCIENCE, 15(11), (1995), D.W. NEWELL et al., "Glutamate and Non-Glutamate Receptor Mediated Toxicity Caused by Oxygen and Glucose Deprivation in Organotypic Hippocampal Cultures", pages 7702-7711.
NEUROSCIENCE, 71(4), (1996), J.B. SCHULTZ et al., "Neuroprotective Strategies for Treatment of Lesions Produced by Mitochondrial Toxins: Implications for Neurodegenerative Diseases", pages 1043-1048.
J. AM. OPTOMETRIC ASSOC., 64(12), (1993), A.M. VAN DER HAGEN et al., "Free Radicals and Antioxidant Supplementation: A Review of Their Roles in Age-Related Macular Degeneration", pages 871-878.
LIEBIGS. ANN. CHEM., (5), (1990), SAMY B. SAID et al., "Synthesis of 2-Alkyl-3-Vinyloxaziridines as Potential Antitumor Agents", pages 461-464.
CHEMICAL ABSTRACTS, Vol. 55, (1961), Abstract No. 23559i.
See also references of EP 0945426A4
Attorney, Agent or Firm:
Nakamura, Toshio (Legal & Patent Dept., 1-98, Kasugadenaka
3-chome, Konohana-k, Osaka-shi Osaka 554, JP)
Download PDF:
Previous Patent: ESTERS OF UNSATURATED FATTY ACIDS
Next Patent: 2-AMINO-1-(4-HYDROXY-2-METHYLPHENYL)PROPANOL DERIVATIVES
Next Patent: 2-AMINO-1-(4-HYDROXY-2-METHYLPHENYL)PROPANOL DERIVATIVES