Title:
NKT CELL LIGAND-CONTAINING LIPOSOME COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/153527
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an NKT cell ligand-containing formulation that can artificially activate NKT cells in vivo and that is useful as an antineoplastic agent or the like. The present invention is a liposome composition containing a glycolipid selected from the group consisting of compounds represented by formula (I), compounds represented by formula (II), and salts thereof. Formula (I): [The symbols in formula (I) are as defined in the specification]. Formula (II): [The symbols in formula (II) are as defined in the specification].
Inventors:
TANIGUCHI MASARU (JP)
OHNO HIROSHI (JP)
TAIDA TAKASHI (JP)
JINNOHARA TOSHI (JP)
TAKAHASHI MASUMI (JP)
MORIYAMA RUI (JP)
HASHIMOTO KOUICHI (JP)
SASAKI TOMOKI (JP)
NAKANO YUTA (JP)
AMARI HIROKUNI (JP)
KIKUCHI HIROSHI (JP)
OHNO HIROSHI (JP)
TAIDA TAKASHI (JP)
JINNOHARA TOSHI (JP)
TAKAHASHI MASUMI (JP)
MORIYAMA RUI (JP)
HASHIMOTO KOUICHI (JP)
SASAKI TOMOKI (JP)
NAKANO YUTA (JP)
AMARI HIROKUNI (JP)
KIKUCHI HIROSHI (JP)
Application Number:
PCT/JP2023/005048
Publication Date:
August 17, 2023
Filing Date:
February 14, 2023
Export Citation:
Assignee:
RIKEN (JP)
LTT BIO PHARMA CO LTD (JP)
NON PROFIT ORGANIZATION JAPAN CLINICAL RES SUPPORT UNIT (JP)
LTT BIO PHARMA CO LTD (JP)
NON PROFIT ORGANIZATION JAPAN CLINICAL RES SUPPORT UNIT (JP)
International Classes:
A61K31/7032; A61K9/127; A61K39/00; A61P31/00; A61P35/00; A61P37/04
Domestic Patent References:
| WO2014133106A1 | 2014-09-04 | |||
| WO2013162016A1 | 2013-10-31 | |||
| WO2009119692A1 | 2009-10-01 | |||
| WO2014001204A1 | 2014-01-03 | |||
| WO2005007172A1 | 2005-01-27 | |||
| WO2014133106A1 | 2014-09-04 | |||
| WO2013162016A1 | 2013-10-31 | |||
| WO2009119692A1 | 2009-10-01 | |||
| WO2014001204A1 | 2014-01-03 | |||
| WO2005007172A1 | 2005-01-27 |
Foreign References:
| JP2008518974A | 2008-06-05 | |||
| JP2016529321A | 2016-09-23 | |||
| JP2008518974A | 2008-06-05 | |||
| JP2016529321A | 2016-09-23 |
Other References:
LONG DAVID E.; KARMAKAR PARTHA; WALL KATHERINE A.; SUCHECK STEVEN J.: "Synthesis of α-l-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibo", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 19, 12 August 2014 (2014-08-12), AMSTERDAM, NL, pages 5279 - 5289, XP029061983, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2014.08.002
LONG DAVID E.; KARMAKAR PARTHA; WALL KATHERINE A.; SUCHECK STEVEN J.: "Synthesis of α-l-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibo", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 19, 12 August 2014 (2014-08-12), AMSTERDAM, NL, pages 5279 - 5289, XP029061983, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2014.08.002
LONG DAVID E.; KARMAKAR PARTHA; WALL KATHERINE A.; SUCHECK STEVEN J.: "Synthesis of α-l-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibo", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 19, 12 August 2014 (2014-08-12), AMSTERDAM, NL, pages 5279 - 5289, XP029061983, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2014.08.002
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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