Title:
NON-ALCOHOLIC FATTY LIVER DISEASE THERAPEUTIC OR PROPHYLACTIC AGENT AND NON-ALCOHOLIC FATTY LIVER DISEASE PROPHYLACTIC FOOD
Document Type and Number:
WIPO Patent Application WO/2018/084224
Kind Code:
A1
Abstract:
Provided are a novel non-alcoholic fatty liver disease therapeutic or prophylactic agent and non-alcoholic fatty liver disease prophylactic food. The present invention is a non-alcoholic fatty liver disease therapeutic or prophylactic agent containing a green-algae-derived substance as an active ingredient. The green-algae-derived substance is chlorella. The present invention is used as a non-alcoholic fatty steatohepatitis therapeutic or prophylactic agent. The present invention is used as a liver fibrosis inhibitor. In addition, the present invention is a non-alcoholic fatty liver disease prophylactic food containing the green-algae-derived substance as an active ingredient.
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Inventors:
NAKASHIMA AYAKA (JP)
OHGO NAOKO (JP)
SUZUKI KENGO (JP)
OHGO NAOKO (JP)
SUZUKI KENGO (JP)
Application Number:
PCT/JP2017/039653
Publication Date:
May 11, 2018
Filing Date:
November 02, 2017
Export Citation:
Assignee:
EUGLENA CO LTD (JP)
International Classes:
A61K36/05; A23L33/10; A61P1/16
Domestic Patent References:
| WO2012157290A1 | 2012-11-22 |
Foreign References:
| JP2006213613A | 2006-08-17 |
Other References:
PANAHI, Y. ET AL.: "Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoHOlic fatty liver disease: a randomized clinical tria l", HEPATO-GASTROENTEROLOGY, vol. 59, no. 119, 2012, pages 2099 - 2103
EBRAHIMI-MAMEGHANI, M. ET AL.: "The Effect of Chlorella vulgaris Supplementation on Liver Enzymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease", HEALTH PROMOT. PERSPECT., vol. 4, no. 1, 2014, pages 107 - 115, XP055482229
WU, LC. ET AL.: "Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts", J. AGRIC. FOOD CHEM., vol. 53, no. 10, 2005, pages 4207 - 4212, XP055482232
NOGUCHI, N. ET AL.: "Chlorella Protein Hydrolysate Attenuates Glucose Metabolic Disorder and Fatty Liver in High-fat Diet-induced Obese Mice", J. OLEO SCIENCE, vol. 65, no. 7, July 2016 (2016-07-01), pages 613 - 620, XP055482235
EBRAHIMI-MAMEGHANI, M. ET AL.: "The Effect of Chlorella vulgaris Supplementation on Liver Enzymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease", HEALTH PROMOT. PERSPECT., vol. 4, no. 1, 2014, pages 107 - 115, XP055482229
WU, LC. ET AL.: "Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts", J. AGRIC. FOOD CHEM., vol. 53, no. 10, 2005, pages 4207 - 4212, XP055482232
NOGUCHI, N. ET AL.: "Chlorella Protein Hydrolysate Attenuates Glucose Metabolic Disorder and Fatty Liver in High-fat Diet-induced Obese Mice", J. OLEO SCIENCE, vol. 65, no. 7, July 2016 (2016-07-01), pages 613 - 620, XP055482235
Attorney, Agent or Firm:
AKIYAMA, Atsushi et al. (JP)
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