Title:
NON-HUMAN GENE-DISRUPTED ANIMAL HAVING ADAM11 GENE DISRUPTION
Document Type and Number:
WIPO Patent Application WO/2007/007787
Kind Code:
A1
Abstract:
Disclosed is a non-human gene-disrupted animal having disrupted ADAM11 gene. A
non-human gene-disrupted animal in which one or both of the alleles of ADAM11 gene
are disrupted.
Inventors:
SAGANE KOJI (JP)
TAKAHASHI EIKI (JP)
YAMAZAKI KAZUTO (JP)
OKI TORU (JP)
TAKAHASHI EIKI (JP)
YAMAZAKI KAZUTO (JP)
OKI TORU (JP)
Application Number:
PCT/JP2006/313862
Publication Date:
January 18, 2007
Filing Date:
July 12, 2006
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
SAGANE KOJI (JP)
TAKAHASHI EIKI (JP)
YAMAZAKI KAZUTO (JP)
OKI TORU (JP)
SAGANE KOJI (JP)
TAKAHASHI EIKI (JP)
YAMAZAKI KAZUTO (JP)
OKI TORU (JP)
International Classes:
A01K67/027; C12N15/09; A61K31/7088; A61K31/713; A61K35/76; A61K38/00; A61K48/00; A61P25/00; A61P25/02; A61P25/28; C12N5/10; C12N15/85; G01N33/15; G01N33/50
Foreign References:
| JP2000093043A | 2000-04-04 |
Other References:
SAGANE K. ET AL.: "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23", GENE, vol. 236, no. 1, 1999, pages 79 - 86, XP003003030
CAPECCHI M.R.: "Altering the genome by homologous recombination", SCIENCE, vol. 244, no. 4910, 1989, pages 1288 - 1292, XP000051938
RYBNIKOVA E. ET AL.: "Developmental regulation and neuronal expression of the cellular disintegrin in ADAM11 gene in mouse nervous system", NEUROSCIENCE, vol. 112, no. 4, 2002, pages 921 - 934, XP003003031
BLOBEL C.P.; WOLFSBERG T.G. ET AL., NATURE, vol. 356, 1992, pages 248 - 252
JUDITH M WHITE., CELL BIOLOGY, vol. 15, 2003, pages 598 - 606
WILBUR, PROC. NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 726 - 730
ALTSCHUL, J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
PEASRON, METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 69
OGURA H; MATSUMOTO M; MIKOSHIBA K., BEHAV BRAIN RES., vol. 122, no. 2, 2001, pages 215 - 219
CAPECCHI M.R.: "Altering the genome by homologous recombination", SCIENCE, vol. 244, no. 4910, 1989, pages 1288 - 1292, XP000051938
RYBNIKOVA E. ET AL.: "Developmental regulation and neuronal expression of the cellular disintegrin in ADAM11 gene in mouse nervous system", NEUROSCIENCE, vol. 112, no. 4, 2002, pages 921 - 934, XP003003031
BLOBEL C.P.; WOLFSBERG T.G. ET AL., NATURE, vol. 356, 1992, pages 248 - 252
JUDITH M WHITE., CELL BIOLOGY, vol. 15, 2003, pages 598 - 606
WILBUR, PROC. NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 726 - 730
ALTSCHUL, J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
PEASRON, METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 69
OGURA H; MATSUMOTO M; MIKOSHIBA K., BEHAV BRAIN RES., vol. 122, no. 2, 2001, pages 215 - 219
Attorney, Agent or Firm:
YOSHITAKE, Kenji et al. (Room 323 Fuji Bldg., 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo 05, JP)
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