Title:
NON-REPLICATING PARAMYXOVIRIDAE VIRUS VECTOR
Document Type and Number:
WIPO Patent Application WO/2008/007581
Kind Code:
A1
Abstract:
A non-replicating SeV vector can be successfully produced which has the deletion of all of genes for NP-protein, P-protein and L-protein (which are RNP-constituting proteins) in genomic RNA. It is confirmed that an NP/P/L-deleted SeV vector having a marker gene (e.g., GFP) integrated therein can achieve high productivity, high foreign gene introduction efficiency and high foreign gene expression efficiency (high MOI infection is required for achieving a high expression level). Since the vector has the deletion of L gene or NP, P and L genes, the quantity of a virus-derived protein expressed in a host cell can be decreased and therefore the immunogenicity upon in-vivo administration can be reduced.
Inventors:
YOU JUN (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
Application Number:
PCT/JP2007/063305
Publication Date:
January 17, 2008
Filing Date:
July 03, 2007
Export Citation:
Assignee:
DNAVEC CORP (JP)
YOU JUN (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
YOU JUN (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
International Classes:
C12N15/09; A61K48/00; C12N7/00; C12N5/10
Domestic Patent References:
| WO2000070070A1 | 2000-11-23 | |||
| WO2003025570A1 | 2003-03-27 | |||
| WO1997016539A1 | 1997-05-09 | |||
| WO1997016538A1 | 1997-05-09 | |||
| WO2005071092A1 | 2005-08-04 | |||
| WO2000070070A1 | 2000-11-23 | |||
| WO1997032010A1 | 1997-09-04 |
Foreign References:
| JPS6230752B2 | 1987-07-03 | |||
| JPS6233879B2 | 1987-07-23 | |||
| JPS6230753B2 | 1987-07-03 | |||
| US5744144A | 1998-04-28 | |||
| US5798100A | 1998-08-25 |
Other References:
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BUCHHOLZ U.J. ET AL.: "Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter", J. VIROL., vol. 73, no. 1, January 1999 (1999-01-01), pages 251 - 259, XP000972290
See also references of EP 2048232A4
BITZER M ET AL., J GENE MED., vol. 5, no. 7, 2003, pages 543 - 553
GRIESENBACH U ET AL., CURR OPIN MOL THER., vol. 7, no. 4, 2005, pages 346 - 352
MOLECULAR THERAPY, vol. 13, no. 1, May 2006 (2006-05-01), pages S185
13TH INTERNATIONAL CONFERENCE NEGATIVE STRAND VIRUSES 2006, 17 June 2006 (2006-06-17)
LAMB, R. A.; D. KOLAKOFSKY, PARAMYXOVIRIDAE: THE VIRUSES AND THEIR REPLICATION, 1996, pages 1177 - 1204
"Fields Virology", RAVEN PRESS
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
KATO A ET AL., J VIROL., vol. 78, 2004, pages 7443 - 54
CALOS, M. P., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 3015
CALAIN, P.; ROUX, L., JOURNAL OF VIROLOGY, vol. 67, no. 8, 1993, pages 4822 - 4830
KATO, A. ET AL., EMBO J., vol. 16, 1997, pages 578 - 587
YU, D. ET AL., GENES CELLS, vol. 2, 1997, pages 457 - 466
KOLAKOFSKI, D. ET AL., J. VIROL., vol. 72, 1998, pages 891 - 899
DURBIN, A.P. ET AL., VIROLOGY, vol. 235, 1997, pages 323 - 332
WHELAN, S. P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 8388 - 8392
SCHNELL. M. J. ET AL., EMBO J., vol. 13, 1994, pages 4195 - 4203
RADECKE, F. ET AL., EMBO J., vol. 14, 1995, pages 5773 - 5784
LAWSON, N. D. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, pages 4477 - 4481
GARCIN, D. ET AL., EMBO J., vol. 14, 1995, pages 6087 - 6094
KATO, A. ET AL., GENES CELLS, vol. 1, 1996, pages 569 - 579
BARON, M.D.; BARRETT, T., J. VIROL., vol. 71, 1997, pages 1265 - 1271
BRIDGEN, A.; ELLIOTT, R.M., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 15400 - 15404
GRAHAM, F. L.; VAN DER EB, J., VIROLOGY, vol. 52, 1973, pages 456
WIGLER, M.; SILVERSTEIN, S., CELL, vol. 11, 1977, pages 223
CALOS, M.P., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 3015
KATO, A., GENES CELLS, vol. 1, 1996, pages 569 - 579
YONEMITSU, Y; KANEDA, Y.: "Molecular Biology of Vascular Diseases. Method in Molecular Medicine", 1999, HUMANA PRESS, article "Hemagglutinating virus of Japan-liposome-mediated gene delivery to vascular cells", pages: 295 - 306
PROC. NATL. ACAD. SCI. USA, vol. 96, no. 15, 1999, pages 8591 - 8596
J. NEUROSURGERY, vol. 90, no. 6, 1999, pages 1115 - 1124
VACCINE, vol. 17, no. 15-16, 1999, pages 1869 - 1882
J. IMMUNOLOGY, vol. 164, 2000, pages 4968 - 4978
KANEKO, H. ET AL., VIROLOGY, vol. 267, 2000, pages 8 - 16
ARAKAWA T ET AL., NATURE BIOTECHNOLOGY, vol. 16, no. 10, 1998, pages 934 - 8
ARAKAWA T ET AL., NATURE BIOTECHNOLOGY, vol. 16, no. 3, 1998, pages 292 - 7
LODMELL DL ET AL., NATURE MEDICINE, vol. 4, no. 8, 1998, pages 949 - 52
J. MED. VIROL, vol. 60, 2000, pages 200 - 204
BUCHHOLZ U.J. ET AL.: "Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter", J. VIROL., vol. 73, no. 1, January 1999 (1999-01-01), pages 251 - 259, XP000972290
See also references of EP 2048232A4
BITZER M ET AL., J GENE MED., vol. 5, no. 7, 2003, pages 543 - 553
GRIESENBACH U ET AL., CURR OPIN MOL THER., vol. 7, no. 4, 2005, pages 346 - 352
MOLECULAR THERAPY, vol. 13, no. 1, May 2006 (2006-05-01), pages S185
13TH INTERNATIONAL CONFERENCE NEGATIVE STRAND VIRUSES 2006, 17 June 2006 (2006-06-17)
LAMB, R. A.; D. KOLAKOFSKY, PARAMYXOVIRIDAE: THE VIRUSES AND THEIR REPLICATION, 1996, pages 1177 - 1204
"Fields Virology", RAVEN PRESS
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
KATO A ET AL., J VIROL., vol. 78, 2004, pages 7443 - 54
CALOS, M. P., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 3015
CALAIN, P.; ROUX, L., JOURNAL OF VIROLOGY, vol. 67, no. 8, 1993, pages 4822 - 4830
KATO, A. ET AL., EMBO J., vol. 16, 1997, pages 578 - 587
YU, D. ET AL., GENES CELLS, vol. 2, 1997, pages 457 - 466
KOLAKOFSKI, D. ET AL., J. VIROL., vol. 72, 1998, pages 891 - 899
DURBIN, A.P. ET AL., VIROLOGY, vol. 235, 1997, pages 323 - 332
WHELAN, S. P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 8388 - 8392
SCHNELL. M. J. ET AL., EMBO J., vol. 13, 1994, pages 4195 - 4203
RADECKE, F. ET AL., EMBO J., vol. 14, 1995, pages 5773 - 5784
LAWSON, N. D. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, pages 4477 - 4481
GARCIN, D. ET AL., EMBO J., vol. 14, 1995, pages 6087 - 6094
KATO, A. ET AL., GENES CELLS, vol. 1, 1996, pages 569 - 579
BARON, M.D.; BARRETT, T., J. VIROL., vol. 71, 1997, pages 1265 - 1271
BRIDGEN, A.; ELLIOTT, R.M., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 15400 - 15404
GRAHAM, F. L.; VAN DER EB, J., VIROLOGY, vol. 52, 1973, pages 456
WIGLER, M.; SILVERSTEIN, S., CELL, vol. 11, 1977, pages 223
CALOS, M.P., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 3015
KATO, A., GENES CELLS, vol. 1, 1996, pages 569 - 579
YONEMITSU, Y; KANEDA, Y.: "Molecular Biology of Vascular Diseases. Method in Molecular Medicine", 1999, HUMANA PRESS, article "Hemagglutinating virus of Japan-liposome-mediated gene delivery to vascular cells", pages: 295 - 306
PROC. NATL. ACAD. SCI. USA, vol. 96, no. 15, 1999, pages 8591 - 8596
J. NEUROSURGERY, vol. 90, no. 6, 1999, pages 1115 - 1124
VACCINE, vol. 17, no. 15-16, 1999, pages 1869 - 1882
J. IMMUNOLOGY, vol. 164, 2000, pages 4968 - 4978
KANEKO, H. ET AL., VIROLOGY, vol. 267, 2000, pages 8 - 16
ARAKAWA T ET AL., NATURE BIOTECHNOLOGY, vol. 16, no. 10, 1998, pages 934 - 8
ARAKAWA T ET AL., NATURE BIOTECHNOLOGY, vol. 16, no. 3, 1998, pages 292 - 7
LODMELL DL ET AL., NATURE MEDICINE, vol. 4, no. 8, 1998, pages 949 - 52
J. MED. VIROL, vol. 60, 2000, pages 200 - 204
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (6F 1-1-1, Oroshi-machi,Tsuchiura-sh, Ibaraki 47, JP)
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