Title:
NONHUMAN MODEL ANIMAL OF HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2007/141974
Kind Code:
A1
Abstract:
It is intended to provide a nonhuman model animal of hypertension which is useful in treating a vascular disease, a method of efficiently screening a drug for preventing and/or treating a vascular disease with the use of the above animal, and a drug obtained by the above method. Namely, a nonhuman model animal of hypertension characterized by completely lacking the function of RAMP1 gene on the chromosome due to the partial or entire modification of the RAMP1 gene. This nonhuman model animal of hypertension can be constructed by, for example, either a method with the use of an ES cell obtained by treating an ES cell containing a region wherein at least a part of the exon of RAMP1 gene is sandwiched between LoxP sequences and another region wherein a selection marker gene is sandwiched between LoxP sequences on the chromosome with Cre enzyme, or a method with the use of mating an RAMP1-floxed mouse having been constructed by using an ES cell containing a region wherein at least a part of the exon of RAMP1 gene is sandwiched between LoxP sequences on the chromosome with a mouse capable of expressing a Cre enzyme.
More Like This:
Inventors:
TSUJIKAWA KAZUTAKE (JP)
YAMAMOTO HIROSHI (JP)
OKABE MASARU (JP)
OKAMOTO HIROSHI (JP)
YAYAMA KATSUTOSHI (JP)
YAMAMOTO HIROSHI (JP)
OKABE MASARU (JP)
OKAMOTO HIROSHI (JP)
YAYAMA KATSUTOSHI (JP)
Application Number:
PCT/JP2007/059316
Publication Date:
December 13, 2007
Filing Date:
May 01, 2007
Export Citation:
Assignee:
UNIV OSAKA (JP)
PCA INTERMED INC (JP)
TSUJIKAWA KAZUTAKE (JP)
YAMAMOTO HIROSHI (JP)
OKABE MASARU (JP)
OKAMOTO HIROSHI (JP)
YAYAMA KATSUTOSHI (JP)
PCA INTERMED INC (JP)
TSUJIKAWA KAZUTAKE (JP)
YAMAMOTO HIROSHI (JP)
OKABE MASARU (JP)
OKAMOTO HIROSHI (JP)
YAYAMA KATSUTOSHI (JP)
International Classes:
A01K67/027; A23L33/00; A61K45/00; A61P9/08; A61P9/10; A61P9/12; A61P25/28; A61P43/00; C12Q1/02; G01N33/15; G01N33/50; C12N15/09
Foreign References:
| JP3639555B2 | 2005-04-20 | |||
| JP2005503809A | 2005-02-10 |
Other References:
QING X. ET AL.: "Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats", AM. J. PHYSIOL. LUNG CELL MOL. PHYSIOL., vol. 285, 2003, pages L86 - L96, XP003019750
TSUJIKAWA K. ET AL.: "RAMP/CRLR Juyotai o Kaishita Calcitonin Idenshi Kanren Peptide (CGR) ni yoru Jujo Saibo, Macrophage no Cytokine Sansei to LPS Yuhatsu Chishi Seigyo", THE JAPANESE SOCIETY FOR IMMUNOLOGY GAKUJUTSU SHUKAI KIROKU, vol. 34, 2004, pages 155 + ABSTR. NO. 2-B-W20-11-O/P, XP003019751
OGITANI Y. ET AL.: "Shinkei Peptide CGRP ni yoru Shizen Men'eki.Kakutoku Men'eki Seigyo Kiko Kaiseki", THE PHARMACEUTICAL SOCIETY JAPAN NENKAI YOSHISHU, vol. 127, no. 2, 5 March 2007 (2007-03-05), pages 29 + ABSTR. NO. 30S-PM04, XP003019752
KATO T. ET AL.: "Hifu Ensho ni okeru Shinkei Peptide CGRP no Yakuwari", THE PHARMACEUTICAL SOCIETY OF JAPAN NENKAI YOSHISHU, vol. 127, no. 2, 5 March 2007 (2007-03-05), pages 29 + ABSTR. NO. 30S-PM08, XP003019753
FUNAYA K. ET AL.: "CGRP Juyotai Knockout Mouse wa, Atarashii Koketsuatsu Model ni Nariuruka?", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 96, pages 120 + ABSTR. NO. 68, XP003019754
MORENO M.J. ET AL.: "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture", NEUROPHARMACOLOGY, vol. 42, 2002, pages 270 - 280, XP003019755
TSUJIKAWA K. ET AL.: "RAMP/CRLR Juyotai o Kaishita Calcitonin Idenshi Kanren Peptide (CGR) ni yoru Jujo Saibo, Macrophage no Cytokine Sansei to LPS Yuhatsu Chishi Seigyo", THE JAPANESE SOCIETY FOR IMMUNOLOGY GAKUJUTSU SHUKAI KIROKU, vol. 34, 2004, pages 155 + ABSTR. NO. 2-B-W20-11-O/P, XP003019751
OGITANI Y. ET AL.: "Shinkei Peptide CGRP ni yoru Shizen Men'eki.Kakutoku Men'eki Seigyo Kiko Kaiseki", THE PHARMACEUTICAL SOCIETY JAPAN NENKAI YOSHISHU, vol. 127, no. 2, 5 March 2007 (2007-03-05), pages 29 + ABSTR. NO. 30S-PM04, XP003019752
KATO T. ET AL.: "Hifu Ensho ni okeru Shinkei Peptide CGRP no Yakuwari", THE PHARMACEUTICAL SOCIETY OF JAPAN NENKAI YOSHISHU, vol. 127, no. 2, 5 March 2007 (2007-03-05), pages 29 + ABSTR. NO. 30S-PM08, XP003019753
FUNAYA K. ET AL.: "CGRP Juyotai Knockout Mouse wa, Atarashii Koketsuatsu Model ni Nariuruka?", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 96, pages 120 + ABSTR. NO. 68, XP003019754
MORENO M.J. ET AL.: "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture", NEUROPHARMACOLOGY, vol. 42, 2002, pages 270 - 280, XP003019755
Attorney, Agent or Firm:
GOTO, Yukihisa et al. (7-16 Higashitenma 2-chome,Kita-k, Osaka-shi Osaka 44, JP)
Download PDF: