Title:
NOVEL 2,6-DIAMINOPYRIMIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2015/033888
Kind Code:
A1
Abstract:
[Problem] To provide a novel 2,6-diaminopyrimidine derivative.
[Solution] A 2,6-diaminopyrimidine derivative represented by formula (I) or a pharmaceutically acceptable salt thereof.
(In the formula, R1 represents a lower alkyl group which may have a substituent, or an alkoxy group which may have a substituent; Ar represents an aryl group which may have a substituent, or a heteroaryl group which may have a substituent; each of Z1 and Z2 represents a carbon atom, or Z1 and/or Z2 represents a nitrogen atom; Q represents a structure selected from structures (a) and (b); R2 represents a lower alkyl group which may have a substituent, or a cycloalkyl group which may have a substituent; R3 represents a hydrogen atom or a halogen atom; Y represents a nitrogen atom or a carbon atom; and a double line composed of a dashed line and a solid line in structure (a) represents a double bond or a single bond.)
Inventors:
KAWAHATA WATARU (JP)
ASAMI TOKIKO (JP)
SAWA MASAAKI (JP)
IRIE TAKAYUKI (JP)
ASAMI TOKIKO (JP)
SAWA MASAAKI (JP)
IRIE TAKAYUKI (JP)
Application Number:
PCT/JP2014/072917
Publication Date:
March 12, 2015
Filing Date:
September 01, 2014
Export Citation:
Assignee:
CARNA BIOSCIENCES INC (JP)
International Classes:
C07D401/10; C07D401/14; A61K31/506; A61K31/5377; A61P19/08; A61P29/00; A61P35/00; A61P37/06
Domestic Patent References:
| WO2013083666A1 | 2013-06-13 | |||
| WO2012135801A1 | 2012-10-04 | |||
| WO2013133367A1 | 2013-09-12 | |||
| WO2013161848A1 | 2013-10-31 | |||
| WO2008033834A1 | 2008-03-20 | |||
| WO2009137596A1 | 2009-11-12 | |||
| WO2013083666A1 | 2013-06-13 |
Foreign References:
| JP2010502749A | 2010-01-28 | |||
| JP2011519948A | 2011-07-14 |
Other References:
SATTERTHWAITE, A. B.; WITTE, 0. N., IMMUNOL. REV., vol. 175, 2000, pages 120 - 127
KUROSAKI T., CURR. OPIN. IMMUNOL., vol. 12, 2000, pages 276 - 281
DAVIS R. E. ET AL., NATURE, vol. 463, 2010, pages 88 - 92
ELLMEIER W. ET AL., FEBS J., vol. 278, 2011, pages 1990 - 2000
HALCOMB K. E., MOL. IMMUNOL., vol. 46, no. 2, 2008, pages 233 - 241
JANSSON L.; HOLMDAHL R., CLIN. EXP. IMMUNOL., vol. 94, 1993, pages 459 - 465
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY&SONS, INC.
N. MIYAURA ET AL., J. AM. CHEM. SOC., vol. 107, 1985, pages 972
N. MIYAURA; A. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457
KUROSAKI T., CURR. OPIN. IMMUNOL., vol. 12, 2000, pages 276 - 281
DAVIS R. E. ET AL., NATURE, vol. 463, 2010, pages 88 - 92
ELLMEIER W. ET AL., FEBS J., vol. 278, 2011, pages 1990 - 2000
HALCOMB K. E., MOL. IMMUNOL., vol. 46, no. 2, 2008, pages 233 - 241
JANSSON L.; HOLMDAHL R., CLIN. EXP. IMMUNOL., vol. 94, 1993, pages 459 - 465
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY&SONS, INC.
N. MIYAURA ET AL., J. AM. CHEM. SOC., vol. 107, 1985, pages 972
N. MIYAURA; A. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457
Attorney, Agent or Firm:
SAMEJIMA Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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