Title:
NOVEL ADENYLOSUCCINATE SYNTHETASE AND METHOD FOR PRODUCING PURINE NUCLEOTIDE USING SAME
Document Type and Number:
WIPO Patent Application WO/2020/027362
Kind Code:
A1
Abstract:
The present application relates to a variant adenylosuccinate synthetase, a microorganism comprising same, and a method for producing purine nucleotide using same.
Inventors:
BAEK MIN JI (KR)
LEE JI HYE (KR)
PARK SO-JUNG (KR)
BAE JEE YEON (KR)
LEE JI HYE (KR)
PARK SO-JUNG (KR)
BAE JEE YEON (KR)
Application Number:
PCT/KR2018/009714
Publication Date:
February 06, 2020
Filing Date:
August 23, 2018
Export Citation:
Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C12N9/00; C12N15/52; C12N15/77; C12P19/32
Foreign References:
| KR20100109732A | 2010-10-11 |
Other References:
DATABASE NCBI 12 January 2017 (2017-01-12), Database accession no. WP _075723579.1
ASAHARA, T. ET AL.: "Accumulation of gene -targeted Bacillus subtilis mutations that enhance fermentative inosine production", APPL. MICROBIOL. BIOTECHNOL, vol. 87, 4 June 2010 (2010-06-04), pages 2195 - 2207, XP019841644
LEDESMA-AMARO, R. ET AL.: "Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii", MICROBIAL CELL FACTORIES, vol. 14, no. 58, 17 April 2015 (2015-04-17), pages 1 - 8, XP021214866
WANG, X. ET AL.: "Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering", JOURNAL OF BIOTECHNOLOGY, vol. 231, 2016, pages 115 - 121, XP055681974, [retrieved on 20160524]
See also references of EP 3831938A4
ASAHARA, T. ET AL.: "Accumulation of gene -targeted Bacillus subtilis mutations that enhance fermentative inosine production", APPL. MICROBIOL. BIOTECHNOL, vol. 87, 4 June 2010 (2010-06-04), pages 2195 - 2207, XP019841644
LEDESMA-AMARO, R. ET AL.: "Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii", MICROBIAL CELL FACTORIES, vol. 14, no. 58, 17 April 2015 (2015-04-17), pages 1 - 8, XP021214866
WANG, X. ET AL.: "Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering", JOURNAL OF BIOTECHNOLOGY, vol. 231, 2016, pages 115 - 121, XP055681974, [retrieved on 20160524]
See also references of EP 3831938A4
Attorney, Agent or Firm:
SON, Min (KR)
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