NOVEL AMIDE DERIVATIVES OR SALTS THEREOF

WIPO Patent Application WO/2003/091213

A1

It is intended to provide compounds of the following general formula (I) which are glycogen phosphorylase inhibitors and useful as remedies and preventives for insulin-dependent diabetes (type 1 diabetes), insulin-independent diabetes (type 2 diabetes), insulin resistant disease and obesity. Namely, glycogen phosphorylase inhibitors characterized by having an indole ring, etc. bonded to a ring A (an aryl ring or an aromatic heterocycle) via an amide bond and the ring A having a hydroxyethylene moiety as a substituent. It is still preferable that the glycogen phosphorylase inhibitors are characterized in that the above-described ring A has a dihydroxyethylene moiety as a substituent. (I) wherein each substituent is as defined in claim 1.

ONDA KENICHI (JP)
SUZUKI TAKAYUKI (JP)
SHIRAKI RYOTA (JP)
YONETOKU YASUHIRO (JP)
OGIYAMA TAKASHI (JP)
MARUYAMA TATSUYA (JP)
MOMOSE KAZUHIRO (JP)

PCT/JP2003/005198

November 06, 2003

April 23, 2003

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YAMANOUCHI PHARMA CO LTD (JP)
ONDA KENICHI (JP)
SUZUKI TAKAYUKI (JP)
SHIRAKI RYOTA (JP)
YONETOKU YASUHIRO (JP)
OGIYAMA TAKASHI (JP)
MARUYAMA TATSUYA (JP)
MOMOSE KAZUHIRO (JP)

A61K31/404; A61K31/407; A61K31/427; A61K31/4439; A61K31/497; A61K31/506; A61P3/04; A61P3/10; A61P43/00; C07D209/42; (IPC1-7): C07D209/42; A61K31/404; A61K31/407; A61K31/427; A61K31/4439; A61K31/497; A61K31/506; A61P3/04; A61P3/10; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07D495/04

WO1996039384A1	1996-12-12
WO1996039385A1	1996-12-12

EP1088824A2

2001-04-04

Nagai, Shozo c/o Yamanouchi Pharmaceutical Co. Ltd. (Patent Department, 17-1, Hasune 3-chom, Itabashi-ku Tokyo, JP)

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