NOVEL ANTI-HUMAN TWEAK ANTIBODY - ASTELLAS PHARMA INC

Title:

NOVEL ANTI-HUMAN TWEAK ANTIBODY

Document Type and Number:

WIPO Patent Application WO/2014/171532

Kind Code:

A1

Abstract:

[Problem] To provide an anti-human TWEAK antibody having superior activity as compared to conventional anti-human TWEAK antibodies, and a means for preventing or treating various diseases in which human TWEAK is involved in the pathogenesis using this antibody. [Solution] Anti-human TWEAK antibody containing each of: a heavy-chain variable region comprising an amino acid sequence of amino acids nos. 1 to 118 of SEQ ID NO: 1, an amino acid sequence of amino acids nos. 1 to 125 of SEQ ID NO: 5, or an amino acid sequence of amino acids nos. 1 to 121 of SEQ ID NO: 9; and a light-chain variable region comprising an amino acid sequence of amino acids nos. 1 to 108 of SEQ ID NO: 3, an amino acid sequence of amino acids nos. 1 to 108 of SEQ ID NO: 7, or an amino acid sequence of amino acids nos. 1 to 108 of SEQ ID NO: 11.

Inventors:

SASAKI TAKANORI (JP)
SATO MASAHITO (JP)

Application Number:

PCT/JP2014/061026

Publication Date:

October 23, 2014

Filing Date:

April 18, 2014

Export Citation:

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Assignee:

ASTELLAS PHARMA INC (JP)

International Classes:

C12N15/09; A61K39/395; A61P9/10; A61P19/02; A61P21/00; A61P25/00; A61P29/00; A61P35/00; A61P37/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08

Foreign References:

JP2008531746A	2008-08-14
JP2008542278A	2008-11-27
JP2012521771A	2012-09-20
US20120121583A1	2012-05-17