Title:
NOVEL ASAROIDOXAZINE C AND ANTI-CANCER USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/121311
Kind Code:
A1
Abstract:
The present invention relates to novel asaroidoxazine C and an anti-cancer use thereof. More specifically, provided are: asaroidoxazine C represented by Formula 1 below, an isomer thereof, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition and a functional health food composition using same; a method for preventing, ameliorating, or treating a cancer using same; and a method for isolating the asaroidoxazine C.
Inventors:
LEE JUN (KR)
SEO YOUNG HYE (KR)
MOON BYEONG CHEOL (KR)
LEE A YEONG (KR)
RYU SEUNG MOK (KR)
KIM HYO SEON (KR)
SEO YOUNG HYE (KR)
MOON BYEONG CHEOL (KR)
LEE A YEONG (KR)
RYU SEUNG MOK (KR)
KIM HYO SEON (KR)
Application Number:
PCT/KR2022/020992
Publication Date:
June 29, 2023
Filing Date:
December 21, 2022
Export Citation:
Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
International Classes:
C07D498/04; A23L33/10; A61K31/5365; A61K36/268; A61P35/00
Foreign References:
| US8883167B2 | 2014-11-11 | |||
| CN112209948A | 2021-01-12 |
Other References:
OHTA SHINJI, OSHIMO SHIORI, OHTA EMI, NEHIRA TATSUO, ÔMURA HISASHI, UY MYLENE M., ISHIHARA YASUHIRO: "Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells", JOURNAL OF NATURAL PRODUCTS, vol. 83, no. 10, 23 October 2020 (2020-10-23), US , pages 3050 - 3057, XP093073848, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.0c00574
GUO HUI-FANG; WANG MYEONG-HYEON: "Dichloromethane fraction ofAsiasarum heterotropoidesinduces S phase arrest and apoptosis in KB oral epithelial carcinoma cells", BIOMEDICINE & PHARMACOTHERAPY, vol. 89, 24 March 2017 (2017-03-24), FR , pages 559 - 564, XP029987151, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2017.02.072
RIOS MARÍA YOLANDA, NAVARRO VÍCTOR, RAMÍREZ-CISNEROS M. ÁNGELES, SALAZAR-RIOS ENRIQUE: "Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis", JOURNAL OF NATURAL PRODUCTS, vol. 80, no. 12, 22 December 2017 (2017-12-22), US , pages 3112 - 3119, XP093075074, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.7b00226
GUO HUI-FANG; WANG MYEONG-HYEON: "Dichloromethane fraction ofAsiasarum heterotropoidesinduces S phase arrest and apoptosis in KB oral epithelial carcinoma cells", BIOMEDICINE & PHARMACOTHERAPY, vol. 89, 24 March 2017 (2017-03-24), FR , pages 559 - 564, XP029987151, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2017.02.072
RIOS MARÍA YOLANDA, NAVARRO VÍCTOR, RAMÍREZ-CISNEROS M. ÁNGELES, SALAZAR-RIOS ENRIQUE: "Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis", JOURNAL OF NATURAL PRODUCTS, vol. 80, no. 12, 22 December 2017 (2017-12-22), US , pages 3112 - 3119, XP093075074, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.7b00226
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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