Title:
NOVEL B0AT1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/145804
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel B0AT1 inhibitor. The present invention relates to a compound represented by formula (I): (the symbols in the formula are as described in the description) or a salt thereof. The present invention also relates to a B0AT1 inhibitor comprising said compound and a preventive and/or therapeutic agent for amino acid metabolism diseases such as phenylketonuria, hypertyrosinemia (types 1-3), hypermethioninemia, maple syrup urine disease, homocystinuria, non-ketotic hyperglycinemia, propionic acidemia, methylmalonic acidemia, and isovaleric acidemia that contains said compound.
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Inventors:
TODOROKI HIDENORI (JP)
SAITO TAKAFUMI (JP)
SHIMOOKA KAZUNARI (JP)
YAMADA TAKAHIRO (JP)
FUKUNAGA KENJI (JP)
KANNO RENTARO (JP)
IMAZU TAKUYA (JP)
SAITO TAKAFUMI (JP)
SHIMOOKA KAZUNARI (JP)
YAMADA TAKAHIRO (JP)
FUKUNAGA KENJI (JP)
KANNO RENTARO (JP)
IMAZU TAKUYA (JP)
Application Number:
PCT/JP2023/002387
Publication Date:
August 03, 2023
Filing Date:
January 26, 2023
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
A61K31/165; A61K31/198; A61K31/223; A61K31/341; A61K31/351; A61K31/397; A61K31/40; A61K31/401; A61K31/415; A61K31/4155; A61K31/4162; A61K31/4166; A61K31/4188; A61K31/4245; A61K31/426; A61K31/429; A61K31/437; A61K31/4375; A61K31/44; A61K31/4402; A61K31/4439; A61K31/445; A61K31/454; A61K31/47; A61K31/472; A61K31/495; A61K31/496; A61K31/4985; A61K31/499; A61K31/4995; A61K31/50; A61K31/5025; A61K31/505; A61K31/519; A61K31/5375; A61K31/5383; A61K31/54; A61K31/55; A61K31/551; A61K31/695; A61P3/00; A61P7/00; A61P13/02; A61P43/00; C07C237/22; C07C317/28; C07D205/04; C07D207/12; C07D207/16; C07D207/50; C07D209/30; C07D209/44; C07D211/16; C07D211/46; C07D213/40; C07D213/61; C07D213/68; C07D215/08; C07D217/06; C07D217/14; C07D217/22; C07D217/24; C07D217/26; C07D223/16; C07D231/12; C07D233/38; C07D237/08; C07D239/26; C07D241/04; C07D241/08; C07D241/12; C07D243/08; C07D265/30; C07D271/06; C07D271/10; C07D277/28; C07D295/185; C07D295/205; C07D295/215; C07D307/14; C07D309/04; C07D401/04; C07D403/04; C07D403/06; C07D413/04; C07D413/12; C07D471/04; C07D487/04; C07D487/08; C07D487/10; C07D498/04; C07D513/04; C07F7/18
Domestic Patent References:
| WO2020210662A1 | 2020-10-15 |
Foreign References:
| JP2013530996A | 2013-08-01 | |||
| JP2013530995A | 2013-08-01 |
Other References:
SHEFALEE K. BHAVSAR; ZOHREH HOSSEINZADEH; KATJA MERCHES; SHUCHEN GU; STEFAN BRER; FLORIAN LANG;: "Stimulation of the amino acid transporter SLC6A19 by JAK2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 414, no. 3, Amsterdam NL , pages 456 - 461, XP028328917, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2011.09.074
DATABASE REGISTRY ANONYMOUS : " - 2-Propenamide, 3-[4-(4-bromo-1H-pyrazol-1-yl)-3-fluorophenyl]-N-[2-oxo-2- (1-piperidinyl)ethyl]- (CA INDEX NAME) ", XP093082165, retrieved from STN
DANTHI SANJAY J., LIANG BEIRONG, SMICKER OANH, COUPLAND BENJAMIN, GREGORY JILL, GEFTEAS ESTELLE, TIETZ DREW, KLODNITSKY HELEN, RAN: "Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays", SLAS DISCOVERY: ADVANCING LIFE SCIENCES R&D, MARY ANN LIEBERT, vol. 24, no. 2, 1 February 2019 (2019-02-01), pages 111 - 120, XP093082161, ISSN: 2472-5552, DOI: 10.1177/2472555218794627
DATABASE REGISTRY ANONYMOUS : " - 2-Propenamide, 3-[4-(4-bromo-1H-pyrazol-1-yl)-3-fluorophenyl]-N-[2-oxo-2- (1-piperidinyl)ethyl]- (CA INDEX NAME) ", XP093082165, retrieved from STN
DANTHI SANJAY J., LIANG BEIRONG, SMICKER OANH, COUPLAND BENJAMIN, GREGORY JILL, GEFTEAS ESTELLE, TIETZ DREW, KLODNITSKY HELEN, RAN: "Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays", SLAS DISCOVERY: ADVANCING LIFE SCIENCES R&D, MARY ANN LIEBERT, vol. 24, no. 2, 1 February 2019 (2019-02-01), pages 111 - 120, XP093082161, ISSN: 2472-5552, DOI: 10.1177/2472555218794627
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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