Title:
NOVEL BENZYLIDENE AZOLIDINE DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/146932
Kind Code:
A1
Abstract:
Provided is a novel compound which has excellent ultraviolet absorbing function (especially UVA absorbing function) and excellent hydrophilicity.
A benzylidene azolidine derivative of the present invention or a salt thereof is characterized by being a benzylidene azolidine derivative represented by specific structural formula (I) or a salt thereof.
(In structural formula (I), n represents an integer of 1-5; A1 represents O, S or N-A4; and each of A2, A3 and A4 independently represents a hydrogen atom, an alkyl group which may be substituted by a hydroxyl group and has 1-8 carbon atoms, or the like (provided that at least one of A2, A3 and A4 contains one or more hydroxyl groups). In this connection, when n is an integer of 2-5, the plurality of A3O- moieties may be the same as or different from each other.)
Inventors:
SHIMIZU TAKASHI (JP)
Application Number:
PCT/JP2013/059112
Publication Date:
October 03, 2013
Filing Date:
March 27, 2013
Export Citation:
Assignee:
ROHTO PHARMA (JP)
International Classes:
C07D233/96; A61K8/49; A61Q17/04; A61Q19/00; C09K3/00
Foreign References:
| US2719141A | 1955-09-27 | |||
| JPH0682856A | 1994-03-25 | |||
| JPH0283384A | 1990-03-23 | |||
| JP2011526616A | 2011-10-13 | |||
| JPH0789838A | 1995-04-04 | |||
| JPH02111760A | 1990-04-24 | |||
| JPH0770084A | 1995-03-14 | |||
| JPH02111760A | 1990-04-24 | |||
| JP3497246B2 | 2004-02-16 |
Other References:
MUDIT M ET AL.: "OPTIMIZATION OF (PHENYLMETHYLIDENE)-HYDANTOINS AS PROSTATE CANCER MIGRATION INHIBITORS: SAR-DIRECTED DESIGN, SYNTHESIS, AND PHARMACOPHORE MODELING", CHEMISTRY & BIODIVERSITY, vol. 8, 2011, pages 1470 - 1485, XP055168611
KATARINA POPOV-PERGAL ET AL.: "Synthesis of 2- (5-arylidene-2,4-dioxotetrahydro-1,3-thiazolyl -3)-ethanols", J. SERB. CHEM. SOC., vol. 60, no. 9, 1995, pages 745 - 748, XP008174853
See also references of EP 2832727A4
KATARINA POPOV-PERGAL ET AL.: "Synthesis of 2- (5-arylidene-2,4-dioxotetrahydro-1,3-thiazolyl -3)-ethanols", J. SERB. CHEM. SOC., vol. 60, no. 9, 1995, pages 745 - 748, XP008174853
See also references of EP 2832727A4
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
Patent business corporation ユニアス international patent firm (JP)
Patent business corporation ユニアス international patent firm (JP)
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