Title:
NOVEL CHIMERIC ANTIGEN RECEPTOR (CAR) HAVING ENHANCED FUNCTIONS
Document Type and Number:
WIPO Patent Application WO/2023/027471
Kind Code:
A1
Abstract:
The present invention relates to: a novel chimeric antigen receptor using, as a backbone of the chimeric antigen receptor, a part of a region of CD99L2, which is known to play a major role in cell adhesion and migration; an immune cell comprising same; and a use thereof. CD99L2-based CAR-T cells exhibit T cell activity and tumor treatment efficiency superior to those of conventional CAR-T cells, and thus can be effectively used in immune cell therapy for cancer treatment.
Inventors:
CHOI KYUNGHO (KR)
CHOI EUN-YOUNG (KR)
NAM GIRI (KR)
CHANG HANNA (KR)
LIM HYEONJI (KR)
YEON HYE-RAN (KR)
PARK HYUNG-BAE (KR)
CHOI EUN-YOUNG (KR)
NAM GIRI (KR)
CHANG HANNA (KR)
LIM HYEONJI (KR)
YEON HYE-RAN (KR)
PARK HYUNG-BAE (KR)
Application Number:
PCT/KR2022/012556
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
TICAROS CO LTD (KR)
International Classes:
C07K14/725; A61K35/17; A61P35/00; C07K14/705; C07K16/28; C12N5/0783
Domestic Patent References:
| WO2019136419A2 | 2019-07-11 |
Foreign References:
| KR20110044374A | 2011-04-29 |
Other References:
SUPANSA PATA;PAVEL OTáHAL;TOMáš BRDIčKA;WITIDA LAOPAJON;KODCHAKORN MAHASONGKRAM;WATCHARA KASINRERK: "Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses", BMC RESEARCH NOTES, BIOMED CENTRAL LTD, GB, vol. 4, no. 1, 13 August 2011 (2011-08-13), GB , pages 293, XP021093071, ISSN: 1756-0500, DOI: 10.1186/1756-0500-4-293
GATTINONI LUCIA , DANIEL J POWELL JR , STEVEN A ROSENBERG , NICHOLAS P RESTIFO : "Adoptive immunotherapy for cancer: building on success", NATURE REVIEWS IMMUNOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 6, no. 5, 1 May 2006 (2006-05-01), London, pages 383 - 393, XP002540348, ISSN: 1474-1733, DOI: 10.1038/nri1842
SJOUKJE J. C. VAN DER STEGEN, HAMIEH MOHAMAD, SADELAIN MICHEL: "The pharmacology of second-generation chimeric antigen receptors", NATURE REVIEWS DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 14, no. 7, 1 July 2015 (2015-07-01), GB , pages 499 - 509, XP055276028, ISSN: 1474-1776, DOI: 10.1038/nrd4597
GATTINONI LUCIA , DANIEL J POWELL JR , STEVEN A ROSENBERG , NICHOLAS P RESTIFO : "Adoptive immunotherapy for cancer: building on success", NATURE REVIEWS IMMUNOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 6, no. 5, 1 May 2006 (2006-05-01), London, pages 383 - 393, XP002540348, ISSN: 1474-1733, DOI: 10.1038/nri1842
SJOUKJE J. C. VAN DER STEGEN, HAMIEH MOHAMAD, SADELAIN MICHEL: "The pharmacology of second-generation chimeric antigen receptors", NATURE REVIEWS DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 14, no. 7, 1 July 2015 (2015-07-01), GB , pages 499 - 509, XP055276028, ISSN: 1474-1776, DOI: 10.1038/nrd4597
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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