NOVEL COMPOSITION FOR GENE DELIVERY - CHONG KUN DANG PHARM CORP

Title:

NOVEL COMPOSITION FOR GENE DELIVERY

Document Type and Number:

WIPO Patent Application WO/2013/070010

Kind Code:

A1

Abstract:

Disclosed is a pharmaceutical composition for gene delivery, comprising: (i) a gene; (ii) a water-soluble chitosan; (iii) a thiamine pyrophosphate or a pharmaceutically acceptable salt thereof; (iv) a protamine or a pharmaceutically acceptable salt thereof; and (v) a neutral or anionic phospholipid. The composition can introduce a gene into cells safely and effectively. Composed of non-toxic and injectable components, the composition is safe for the body and can be advantageously commercialized. Notably, it can deliver a gene at high efficiency in vivo as well as in vitro, and is stable in the blood.

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Inventors:

LEE YOUNG NAM (KR)
HWANG HO YOUNG (KR)
NOH SANG MYOUNG (KR)
CHO HEE-JEONG (KR)
CHAE AH-REUM (KR)
LEE JI HEE (KR)
KI MIN HYO (KR)
LIM JONG LAE (KR)

Application Number:

PCT/KR2012/009443

Publication Date:

May 16, 2013

Filing Date:

November 09, 2012

Export Citation:

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Assignee:

CHONG KUN DANG PHARM CORP (KR)

International Classes:

A61K38/17

Domestic Patent References:

WO2004074314A2	2004-09-02
WO1999036089A1	1999-07-22

Foreign References:

US20100113559A1	2010-05-06
US20100040694A1	2010-02-18
US7361640B2	2008-04-22
US20110038941A1	2011-02-17
US20030068277A1	2003-04-10
US20030212031A1	2003-11-13
KR20040058199A	2004-07-03

Other References:

KUMAR ET AL.: "Chitosan IFN- y -pDNA Nanoparticle (CIN) Therapy for Allergic Asthma", GENETIC VACCINES AND THERAPY, vol. 1, no. 3, 27 October 2003 (2003-10-27), pages 1 - 10, XP021009738
THE AAPS JOURNAL, vol. 12, 2010, pages 492 - 503
PHARMACEUTICAL RESEARCH, vol. 11, 1994, pages 1127 - 1131
TRENDS IN FOOD SCIENCE & TECHNOLOGY, vol. 18, 2007, pages 117 - 131
PHARMACEUTICAL RESEARCH, vol. 25, 2008, pages 2807 - 2814
EXPERT OPINION ON DRUG DELIVERY, vol. 8, 2011, pages 343 - 357
See also references of EP 2776056A4

Attorney, Agent or Firm:

AHN, So-Young (Shinseung Bldg. 1676-1, Seocho-dong,,Seocho-gu, Seoul 137-881, KR)

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