NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS

Title:

NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS

Document Type and Number:

WIPO Patent Application WO2002051983

Kind Code:

A3

Abstract:

The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making

Inventors:

GRAUPE MICHAEL (US)
PATTERSON JOHN (US)
PICKETT STEPHEN D (US)
LINK JOHN (US)
LI JIAYAO (US)
ALDOUS DAVID (US)
THURAIRATNAM SUKANTHINI (US)
TIMM ANDREAS (US)
HALLEY FRANK (US)
LAI JUSTINE (US)

Application Number:

PCT/US2001/050680

Publication Date:

November 06, 2003

Filing Date:

December 24, 2001

Export Citation:

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Assignee:

AXYS PHARM INC (US)
AVENTIS PHARMA INC (US)
GRAUPE MICHAEL (US)
PATTERSON JOHN (US)
PICKETT STEPHEN D (US)
LINK JOHN (US)
LI JIAYAO (US)
ALDOUS DAVID (US)
THURAIRATNAM SUKANTHINI (US)
TIMM ANDREAS (US)
HALLEY FRANK (US)
LAI JUSTINE (US)

International Classes:

A61K31/165; A61K31/277; A61K31/423; A61K31/4245; A61K31/425; A61K31/437; A61K31/454; A61K31/5375; A61K31/5377; A61K31/55; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P19/02; A61P21/04; C07D295/18; A61P25/00; A61P25/28; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07C317/44; C07C317/50; C07C323/60; C07D205/08; C07D205/085; C07D207/24; C07D207/273; C07D213/40; C07D223/10; C07D223/12; C07D263/06; C07D263/32; C07D263/56; C07D271/06; C07D271/10; C07D277/26; C07D277/64; C07D285/08; C07D295/185; C07D413/04; C07D413/12; C07D498/04; C07D207/26; (IPC1-7): C07D263/56; C07D277/64; C07D295/18; C07C317/44; C07D271/06; C07C323/60; C07D205/08; C07D277/26; C07C317/50; C07D207/26; C07D223/10; C07D498/04; C07D271/10; C07D413/04; C07D223/12; A61K31/16; A61P29/00

Domestic Patent References:

WO2000048992A1	2000-08-24
WO2001009110A1	2001-02-08

Other References: