NOVEL COMPOUNDS HAVING ANTIVIRAL ACTIVITY

WIPO Patent Application WO/1997/043296

A1

Compounds comprising of glycosides wherein a lipid is bonded to the 2-position of a sialic acid completely sulfated on the hydroxyl groups at the 4-, 7-, 8- and 9-positions or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) completely sulfated on the hydroxyl groups at the 4-, 5-, 7-, 8- and 9-positions or salts thereof. These compounds have an antiretroviral activity with little anti coagulant activity and cytotoxicity.

FUJITA SHUJI (JP)
NUMATA MASAAKI (JP)
SUZUKI KAZUO (JP)
NUNOMURA SHIGEKI (JP)
SUGIMOTO MAMORU (JP)
TERADA MASAKI (JP)

PCT/JP1997/001654

November 20, 1997

May 16, 1997

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NISSIN FOOD PRODUCTS LTD (JP)
FUJITA SHUJI (JP)
NUMATA MASAAKI (JP)
SUZUKI KAZUO (JP)
NUNOMURA SHIGEKI (JP)
SUGIMOTO MAMORU (JP)
TERADA MASAKI (JP)

C07H15/04; C07H15/06; C07H15/10; C07H15/14; C07H15/203; (IPC1-7): C07H15/04; C07H15/14

EP0771815A1	1997-05-07
JPH0317020A	1991-01-25
JPH06234788A	1994-08-23
JPH0841093A	1996-02-13
JPH03246297A	1991-11-01

EUR. J. MED. CHEM., Vol. 31, No. 5, (1996), S. SAITO et al., "Synthetic Studies on the Relationship Between Anti-HIV Activities and Micelle Forming Abilities of Various Alkylated Glycyrrhetinate Diglycoside Sodium Sulfates and Related Compounds", pages 365-381.
CARBOHYDR. RES., Vol. 230, No. 2, (1992), T. BOCHER et al., "Synthesis and Properties of Sulfated Alkyl Glycosides", pages 245-256.
J. MED. CHEM., Vol. 34, No. 10, (1991), P.L. TOOGOOD et al., "Monovalent Sialosides that Bind to Influenza A Virus", pages 3138-3140.

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