Title:
NOVEL COMPOUNDS AND PROCESS FOR THEIR PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2003/035605
Kind Code:
A1
Abstract:
Compounds represented by the general formula: RO−CH(CN)2 (wherein R is a monovalent organic group), which are useful as carbon−addition reagent, can be produced efficiently and in a high yield. Specifically, a process for production of compounds represented by the general formula (2): (2) (wherein R is a monovalent organic or organometallic group), characterized by adding peracetic acid to a compound represented by the general formula: (1) (wherein R” is alkyl or aryl), stirring the resulting mixture to conduct oxidative cleavage, and adding a hydroxyl−protecting reagent to the obtained crude product to protect the hydroxyl group.
Inventors:
NEMOTO HISAO (JP)
Application Number:
PCT/JP2002/011054
Publication Date:
May 01, 2003
Filing Date:
October 24, 2002
Export Citation:
Assignee:
TECHNO NETWORK SHIKOKU CO LTD (JP)
EISAI CO LTD (JP)
NEMOTO HISAO (JP)
EISAI CO LTD (JP)
NEMOTO HISAO (JP)
International Classes:
C07C255/16; C07F7/18; (IPC1-7): C07C255/16; C07C253/30; C07F7/08
Foreign References:
| DE2807935A1 | 1979-08-30 | |||
| JPH05119486A | 1993-05-18 |
Other References:
NEMOTO HISAO; KUBOTA ET AL.: "Development of a new acyl anion equivalent for the preparation of masked activated esters and their use to prepare a dipeptide", JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 15, 1990, pages 4515 - 4516, XP002165046
LEV I.J. ET AL.: "Photogeneration and reactions of acyclic carbonyl ylides", JOURNAL OF ORGANIC CHEMISTRY, vol. 41, no. 15, 1976, pages 2654 - 2656, XP002961082
LEV I.J. ET AL.: "Photogeneration and reactions of acyclic carbonyl ylides", JOURNAL OF ORGANIC CHEMISTRY, vol. 41, no. 15, 1976, pages 2654 - 2656, XP002961082
Attorney, Agent or Firm:
Furuya, Kaoru (Nihonbashi-Hamacho Chuo-ku, Tokyo, JP)
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