Title:
NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2011/162368
Kind Code:
A1
Abstract:
Disclosed is a novel compound which has an activity of promoting the secretion of insulin from a pancreatic β cell and is useful as a prophylactic and/or therapeutic agent for diseases associated with hyperglycemia, such as diabetes. Specifically disclosed is a compound represented by general formula (1) [wherein one of A and B represents a nitrogen atom and the other represents a nitrogen atom or CR10; X represents an oxygen atom, a sulfur atom or -(CH2)n-N(R12)-; Y represents an oxygen atom, a sulfur atom or -N(R13)-; and R1 to R9 independently represent a hydrogen atom or another substituent], a salt thereof, or a solvate of the compound or the salt.
Inventors:
MORIMOTO TOSHIHARU (JP)
KOSHIZAWA TOMOAKI (JP)
WATANABE GEN (JP)
OHGIYA TADAAKI (JP)
YAMASAKI NAO (JP)
INOUE NORIYUKI (JP)
KOSHIZAWA TOMOAKI (JP)
WATANABE GEN (JP)
OHGIYA TADAAKI (JP)
YAMASAKI NAO (JP)
INOUE NORIYUKI (JP)
Application Number:
PCT/JP2011/064515
Publication Date:
December 29, 2011
Filing Date:
June 24, 2011
Export Citation:
Assignee:
KOWA CO (JP)
MORIMOTO TOSHIHARU (JP)
KOSHIZAWA TOMOAKI (JP)
WATANABE GEN (JP)
OHGIYA TADAAKI (JP)
YAMASAKI NAO (JP)
INOUE NORIYUKI (JP)
MORIMOTO TOSHIHARU (JP)
KOSHIZAWA TOMOAKI (JP)
WATANABE GEN (JP)
OHGIYA TADAAKI (JP)
YAMASAKI NAO (JP)
INOUE NORIYUKI (JP)
International Classes:
C07D487/04; A61K31/519; A61P3/10; C07D491/048; C07D495/04
Domestic Patent References:
| WO2009041567A1 | 2009-04-02 | |||
| WO2009127321A1 | 2009-10-22 | |||
| WO2007115822A1 | 2007-10-18 | |||
| WO2006077401A1 | 2006-07-27 | |||
| WO2005113560A2 | 2005-12-01 | |||
| WO2009070524A1 | 2009-06-04 | |||
| WO2004065389A1 | 2004-08-05 | |||
| WO2009115496A1 | 2009-09-24 | |||
| WO2002057271A2 | 2002-07-25 |
Foreign References:
| JP2009532407A | 2009-09-10 | |||
| JP2009526761A | 2009-07-23 | |||
| JP2008514700A | 2008-05-08 | |||
| JP2008222557A | 2008-09-25 |
Other References:
See also references of EP 2586781A4
J CLIN ENDOCRINOL METAB, vol. 89, no. 5, May 2004 (2004-05-01), pages 2078 - 2084
REGUL PEPT, vol. 117, no. 2, 2004, pages 77 - 88
THE LANCET, vol. 2, 31 August 1985 (1985-08-31), pages 474 - 475
THE LANCET, vol. 352, 12 September 1998 (1998-09-12), pages 837 - 853
"Progress in Medicine", LIFESCIENCE MEDICA, vol. 5, 1985, pages 2157 - 2161
"Bunshi Sekkei (Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Iyakuhin no Kaihatsu (Development of Medicine", pages: 163 - 198
"Protective Groups inorganic Synthesis Third Edition", 1999, JOHN WILEY & SONS, INC.
"Comprehensive Organic Transformations Second Edition", 1999, JOHN WILEY & SONS, INC
A. R. MUCI; S. L. BUCHWALD, TOP. CURR. CHEM., vol. 219, 2002, pages 131 - 209
J. ORG. CHEM., vol. 47, 1982, pages 4633 - 4637
J CLIN ENDOCRINOL METAB, vol. 89, no. 5, May 2004 (2004-05-01), pages 2078 - 2084
REGUL PEPT, vol. 117, no. 2, 2004, pages 77 - 88
THE LANCET, vol. 2, 31 August 1985 (1985-08-31), pages 474 - 475
THE LANCET, vol. 352, 12 September 1998 (1998-09-12), pages 837 - 853
"Progress in Medicine", LIFESCIENCE MEDICA, vol. 5, 1985, pages 2157 - 2161
"Bunshi Sekkei (Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Iyakuhin no Kaihatsu (Development of Medicine", pages: 163 - 198
"Protective Groups inorganic Synthesis Third Edition", 1999, JOHN WILEY & SONS, INC.
"Comprehensive Organic Transformations Second Edition", 1999, JOHN WILEY & SONS, INC
A. R. MUCI; S. L. BUCHWALD, TOP. CURR. CHEM., vol. 219, 2002, pages 131 - 209
J. ORG. CHEM., vol. 47, 1982, pages 4633 - 4637
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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