Title:
NOVEL CYCLOALKENONE COMPOUND OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/030606
Kind Code:
A1
Abstract:
A compound represented by general formula (I) or a salt thereof; a nerve growth promoter containing the compound or salt as the active ingredient; a medicinal composition containing the compound or salt; a therapeutic agent for neurodegenerative diseases which contains the compound or salt as the active ingredient; a therapeutic agent for amyotrophic lateral scleroses which contains the compound or salt as the active ingredient; a therapeutic agent for pains which contains the compound or salt as the active ingredient; and a therapeutic agent for lower urinary disorders which contains the compound or salt as the active ingredient.
Inventors:
SHIGENO KAZUHIKO (JP)
NOMA TAKAHISA (JP)
HAKOZAKI ATSUSHI (JP)
NOMA TAKAHISA (JP)
HAKOZAKI ATSUSHI (JP)
Application Number:
PCT/JP2021/029246
Publication Date:
February 10, 2022
Filing Date:
August 06, 2021
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07C49/753; A61K31/075; A61K31/122; A61K31/13; A61K31/16; A61K31/27; A61K31/275; A61P13/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/28; A61P29/02; A61P43/00; C07C235/78; C07C255/31; C07C271/12
Domestic Patent References:
| WO1999008987A1 | 1999-02-25 | |||
| WO2017125087A1 | 2017-07-27 |
Foreign References:
| JP2001515058A | 2001-09-18 | |||
| JP2002241271A | 2002-08-28 | |||
| JP2019504018A | 2019-02-14 | |||
| JP2011513423A | 2011-04-28 |
Other References:
VENIT JOHN J., MICHAEL DIPIERRO, PHILIP MAGNUS: "Studies on the synthesis of 1-azaspiro[5.5]undecanes related to histrionicotoxin", J. ORG. CHEM., vol. 54, no. 109, 31 December 1989 (1989-12-31), pages 4298 - 4301, XP055894455, DOI: 10.1021/jo00279a014
GREWE RUDOLF, ELISABETH NOLTE, RUDI-HEINZ ROTZOLL: "Syntheses of 3-substituted cyclohexenone derivatives", CHEMISCHE BERICHTE, vol. 89, 31 December 1956 (1956-12-31), pages 600 - 610, XP055894454, DOI: 10.1002/Cber.19560890304
LEE EUN, DAE SUNG LEE: "Alkylation and spiroannulation of 3-bromo-2-cycloalken-1-ones via radical intermediates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 31, no. 30, 31 December 1990 (1990-12-31), Amsterdam , NL , pages 4341 - 4342, XP055894451, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)97616-0
YEH M. C. P., KNOCHEL P., BUTLER W. M., ET AL.: "1,4-ADDITIONS OF THE HIGHLY FUNCTIONALIZED COPPER REAGENTS RCU(CN)ZNI.2 BF3 TO TRISUBSTITUTED ENONES. A NEW BF3 PROMOTED CYCLIZATION REACTION.", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 29., no. 51., 1 January 1988 (1988-01-01), Amsterdam , NL , pages 6693 - 6696., XP000020568, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)82430-2
KOTERA MASASHI, KEITARO ISHII, OSAMU TAMURA, MASANORI SAKAMOTO: "1,3-Dipolar cycloadditions of photoinduced carbonyl ylides. Part 2. Photoreactions of α,β-unsaturated γ,δ-epoxy dinitriles and ethyl vinyl ether", J. CHEM. SOC. PERKIN TRANS, vol. 2, 31 December 1998 (1998-12-31), pages 313 - 318, XP055894447, DOI: 10.1039/A704632D
DATABASE REGISTRY 17 April 2017 (2017-04-17), ANONYMOUS : "1-Cyclohexene-1-acetonitrile, 2-methyl-3-oxo- (CA INDEX NAME)", XP055894458, retrieved from STN Database accession no. 2091122-48-2 (+1824492-73-0)
NOBUO IZUMIYA ET AL.: "peptide gosei no kiso to jikken for these methods", 1983, MARUZEN PUBLISHING CO.
TETRAHEDRON, vol. 54, no. 27, 1998, pages 7735 - 7748
SAITOH ET AL., EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 501, 2004, pages 143 - 149
TOPALLI ET AL., BRAIN RESEARCH, vol. 1030, 2004, pages 116 - 124
GREWE RUDOLF, ELISABETH NOLTE, RUDI-HEINZ ROTZOLL: "Syntheses of 3-substituted cyclohexenone derivatives", CHEMISCHE BERICHTE, vol. 89, 31 December 1956 (1956-12-31), pages 600 - 610, XP055894454, DOI: 10.1002/Cber.19560890304
LEE EUN, DAE SUNG LEE: "Alkylation and spiroannulation of 3-bromo-2-cycloalken-1-ones via radical intermediates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 31, no. 30, 31 December 1990 (1990-12-31), Amsterdam , NL , pages 4341 - 4342, XP055894451, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)97616-0
YEH M. C. P., KNOCHEL P., BUTLER W. M., ET AL.: "1,4-ADDITIONS OF THE HIGHLY FUNCTIONALIZED COPPER REAGENTS RCU(CN)ZNI.2 BF3 TO TRISUBSTITUTED ENONES. A NEW BF3 PROMOTED CYCLIZATION REACTION.", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 29., no. 51., 1 January 1988 (1988-01-01), Amsterdam , NL , pages 6693 - 6696., XP000020568, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)82430-2
KOTERA MASASHI, KEITARO ISHII, OSAMU TAMURA, MASANORI SAKAMOTO: "1,3-Dipolar cycloadditions of photoinduced carbonyl ylides. Part 2. Photoreactions of α,β-unsaturated γ,δ-epoxy dinitriles and ethyl vinyl ether", J. CHEM. SOC. PERKIN TRANS, vol. 2, 31 December 1998 (1998-12-31), pages 313 - 318, XP055894447, DOI: 10.1039/A704632D
DATABASE REGISTRY 17 April 2017 (2017-04-17), ANONYMOUS : "1-Cyclohexene-1-acetonitrile, 2-methyl-3-oxo- (CA INDEX NAME)", XP055894458, retrieved from STN Database accession no. 2091122-48-2 (+1824492-73-0)
NOBUO IZUMIYA ET AL.: "peptide gosei no kiso to jikken for these methods", 1983, MARUZEN PUBLISHING CO.
TETRAHEDRON, vol. 54, no. 27, 1998, pages 7735 - 7748
SAITOH ET AL., EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 501, 2004, pages 143 - 149
TOPALLI ET AL., BRAIN RESEARCH, vol. 1030, 2004, pages 116 - 124
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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