Title:
NOVEL DIHYDROTRIAZINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/024225
Kind Code:
A1
Abstract:
A compound represented by general formula (1), a tautomer thereof, or a salt of the compound or tautomer, which is useful as a bactericide/disinfectant. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like, R2 represents a hydrogen atom or an optionally substituted alkyl group, or alternatively R1 and R2 may combine together with an adjacent nitrogen atom to form an optionally substituted nitrogen-containing heterocyclic group; R4 represents a hydrogen atom or an optionally substituted alkyl group; R3 represents an optionally substituted alkyl group; and R5 and R6 each represents a hydrogen atom or a methyl group. In this connection, a compound wherein both R2 and R4 represent a hydrogen atom and a compound wherein both R1 and R4 represent a hydrogen atom are excluded.)
Inventors:
MAEDA SHIROU (JP)
MAEDA AKIHISA (JP)
MAEDA AKIHISA (JP)
Application Number:
PCT/JP2009/064739
Publication Date:
March 04, 2010
Filing Date:
August 24, 2009
Export Citation:
Assignee:
HAMARI CHEMICALS LTD (JP)
MAEDA SHIROU (JP)
MAEDA AKIHISA (JP)
MAEDA SHIROU (JP)
MAEDA AKIHISA (JP)
International Classes:
C07D251/10; A61K8/43; A61K8/49; A61K31/155; A61K31/53; A61P31/02; A61P31/04; C07C279/26
Domestic Patent References:
| WO2001053276A1 | 2001-07-26 | |||
| WO2004054989A1 | 2004-07-01 | |||
| WO2004054989A1 | 2004-07-01 |
Foreign References:
| JP2003520858A | 2003-07-08 | |||
| JPS59206347A | 1984-11-22 | |||
| JPS59210062A | 1984-11-28 | |||
| JPS59210061A | 1984-11-28 | |||
| JPS59210068A | 1984-11-28 | |||
| JPS59225175A | 1984-12-18 | |||
| JPS5151531A | 1976-05-07 | |||
| US5565451A | 1996-10-15 | |||
| EP0504290B1 | 1997-01-22 | |||
| US3682912A | 1972-08-08 | |||
| US3723429A | 1973-03-27 | |||
| US3287365A | 1966-11-22 | |||
| US3287366A | 1966-11-22 | |||
| JP2008215765A | 2008-09-18 |
Other References:
WALSH, R.J. ET AL.: "The structure activity relationship of antibacterial substituted 1-phenyl-4,6-diamino-1,2-dihydro-2,2-dimethyl- s-triazines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 12, no. 6, 1977, pages 495 - 500, XP002978031
CHEMICAL ABSTRACTS, vol. 50, no. 77936, 1956, Columbus, Ohio, US; abstract no. 875239-00-2, XP008145779
CHEMICAL ABSTRACTS, vol. 62, no. 58617, 1965, Columbus, Ohio, US; abstract no. 1934-81-2, XP008145778
CHEMICAL ABSTRACTS, vol. 49, no. 53575, 1955, Columbus, Ohio, US; abstract no. 850638-02-7, XP008145776
OLAR, R. ET AL.: "Thermal behavior of some N,N-dimethylbiguanide derivatives displaying antimicrobial activity", JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 88, no. 2, 2007, pages 323 - 327, XP019505541
CHEMICAL ABSTRACTS, vol. 56, no. 33977, 1962, Columbus, Ohio, US; abstract no. 17968-76-2, XP008145777
DAVIES, A. ET AL.: "Action of biguanides, phenols, and detergents on Escherichia coli and its spheroplasts", JOURNAL OF APPLIED BACTERIOLOGY, vol. 32, no. 2, 1969, pages 233 - 243, XP008145529
KELAREV, V.I. ET AL.: "Synthesis of N-substituted 6-alkyl-2,4-diamino-1,3,5-triazines containing long alkyl radicals", ZHURNAL ORGANICHESKOI KHIMII, vol. 24, no. 5, 1988, pages 1100 - 1105, XP008145552
JOURNAL OF PHARMACOLOGY, vol. 2, 1947, pages 161 - 168
BRITISH H. C. CARRINGTON ET AL., NATURE, vol. 168, 1951, pages 1080 1
E. J. MODEST ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 74, 1952, pages 855 - 856
E. J. MODEST ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 21, 1956, pages 1 - 13,14-20
ANDRE ROSOWSKY ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 39, 1995, pages 79 - 86
See also references of EP 2332925A4
CHEMICAL ABSTRACTS, vol. 50, no. 77936, 1956, Columbus, Ohio, US; abstract no. 875239-00-2, XP008145779
CHEMICAL ABSTRACTS, vol. 62, no. 58617, 1965, Columbus, Ohio, US; abstract no. 1934-81-2, XP008145778
CHEMICAL ABSTRACTS, vol. 49, no. 53575, 1955, Columbus, Ohio, US; abstract no. 850638-02-7, XP008145776
OLAR, R. ET AL.: "Thermal behavior of some N,N-dimethylbiguanide derivatives displaying antimicrobial activity", JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 88, no. 2, 2007, pages 323 - 327, XP019505541
CHEMICAL ABSTRACTS, vol. 56, no. 33977, 1962, Columbus, Ohio, US; abstract no. 17968-76-2, XP008145777
DAVIES, A. ET AL.: "Action of biguanides, phenols, and detergents on Escherichia coli and its spheroplasts", JOURNAL OF APPLIED BACTERIOLOGY, vol. 32, no. 2, 1969, pages 233 - 243, XP008145529
KELAREV, V.I. ET AL.: "Synthesis of N-substituted 6-alkyl-2,4-diamino-1,3,5-triazines containing long alkyl radicals", ZHURNAL ORGANICHESKOI KHIMII, vol. 24, no. 5, 1988, pages 1100 - 1105, XP008145552
JOURNAL OF PHARMACOLOGY, vol. 2, 1947, pages 161 - 168
BRITISH H. C. CARRINGTON ET AL., NATURE, vol. 168, 1951, pages 1080 1
E. J. MODEST ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 74, 1952, pages 855 - 856
E. J. MODEST ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 21, 1956, pages 1 - 13,14-20
ANDRE ROSOWSKY ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 39, 1995, pages 79 - 86
See also references of EP 2332925A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF: