PROPHYLACTIC OR THERAPEUTIC AGENT FOR BONE/JOINT DISEASES COMPRISING, AS ACTIVE INGREDIENT, PYRROLE DERIVATIVE HAVING UREIDE GROUP, AMINOCARBONYL GROUP AND SUBSTITUTED PHENYL GROUP AS SUBSTITUENTS

Title:

PROPHYLACTIC OR THERAPEUTIC AGENT FOR BONE/JOINT DISEASES COMPRISING, AS ACTIVE INGREDIENT, PYRROLE DERIVATIVE HAVING UREIDE GROUP, AMINOCARBONYL GROUP AND SUBSTITUTED PHENYL GROUP AS SUBSTITUENTS

Document Type and Number:

WIPO Patent Application WO/2010/024226

Kind Code:

A1

Abstract:

Disclosed is a compound useful for the prevention or treatment of bone/joint diseases such as rheumatoid arthritis, juvenile rheumatoid arthritis, Still's disease, osteoarthritis, osteoporosis, chondrodystrophy, osteodystrophy, spondylarthritis, psoriatic arthritis, arthritis, synovitis, or joint disorders induced by sports, accidents or the like. A compound represented by general formula (1) or a salt thereof prevents the paw swelling effectively in a collagen-induced arthritic rat model, and is therefore useful as a prophylactic or therapeutic agent for the above-mentioned bone/joint diseases. In the formula, R1 represents a hydrogen atom, or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like; R3 represents a hydrogen atom, or the like; and n represents a number of 0, 1 or 2, provided that multiple R2's may be the same as or different from each other when n is 2.

Inventors:

MURAI MASAAKI (JP)
TSUJI FUMIO (JP)
ENOMOTO HIROSHI (JP)
KAWASHIMA KENJI (JP)
KAWASHIMA NORIKO (JP)
KUDOU KAZUHIRO (JP)
YAMAMOTO MINORU (JP)

Application Number:

PCT/JP2009/064743

Publication Date:

March 04, 2010

Filing Date:

August 25, 2009

Export Citation:

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
MURAI MASAAKI (JP)
TSUJI FUMIO (JP)
ENOMOTO HIROSHI (JP)
KAWASHIMA KENJI (JP)
KAWASHIMA NORIKO (JP)
KUDOU KAZUHIRO (JP)
YAMAMOTO MINORU (JP)

International Classes:

C07D207/34; A61K31/40; A61P19/00; A61P19/04; A61P19/10; A61P29/00

Domestic Patent References:

WO2008105408A1	2008-09-04
WO2008087933A1	2008-07-24
WO2007103468A2	2007-09-13
WO2005123671A1	2005-12-29

Foreign References:

JP2003522766A

2003-07-29

Other References:

PODOLIN, P.L. ET AL.: "Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IKB kinase 2, TPCA-1(2-[(aminocarbonyl)amino]-5- (4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 312, no. 1, 2005, pages 373 - 381

Attorney, Agent or Firm:

HIBI, Norihiko et al. (JP)
Norihiko Hibi (JP)

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