Title:
NOVEL ERGOSTENOL GLYCOSIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/135699
Kind Code:
A1
Abstract:
The present invention provides a novel ergostenol glycoside derivative. The ergostenol and the glycoside derivative thereof according to the present invention suppresses the production of chemokines increasing according to the skin inflammation stimulation and inhibits the activity of transcriptional factors controlling the expression of various inflammation mediators in the prevention and treatment of dermatitis, and thus can be favorably used as an agent for preventing and treating dermatitis or as a cosmetic material for alleviating atopy.
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Inventors:
KIM HAKWON (KR)
LEE TAE HOON (KR)
PARK HOONGYU (KR)
OH HYUNJEONG (KR)
LEE TAE HOON (KR)
PARK HOONGYU (KR)
OH HYUNJEONG (KR)
Application Number:
PCT/KR2017/003183
Publication Date:
July 26, 2018
Filing Date:
March 24, 2017
Export Citation:
Assignee:
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
C07J17/00; A61K8/60; A61K31/704; A61Q19/00; C07J9/00
Foreign References:
| CN102940606A | 2013-02-27 |
Other References:
TONG, J. ET AL.: "Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters", MARINE DRUGS, vol. 10, 2012, pages 521 - 538, XP055505872
YI, C. ET AL.: "Enhanced Oral Bioavailability of a Sterol-loaded Microemulsion Formulation of Flammulina Velutipes, a Potential Antitumor Drug", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 7, no. 19, 2012, pages 5067 - 5078, XP055505870
YI, C. ET AL.: "Enhanced Oral Bioavailability and Tissue Distribution of a New Potential Anticancer Agent, Flammulina Velutipes Sterols, through Liposomal Encapsulation", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 61, no. 25, 2013, pages 5961 - 5971, XP055505873
MISHARSN, A. Y. ET AL.: "Novel Side Chain Modified A8(14)-15-ketosterols", STEROIDS, vol. 72, no. 3, 20 February 2007 (2007-02-20), pages 305 - 312, XP005896012
PETER J. BARNES: "Corticosteroids, IgE, and atopy", J CLIN INVEST., vol. 107, no. 3, 1 February 2001 (2001-02-01), pages 265 - 266
CURY MARTINS J ET AL.: "Topical tacrolimus for atopic dermatitis.", COCHRANE DATABASE SYST REV, 1 July 2015 (2015-07-01)
"Remington's Pharmaceutical Science (latest version", MACK PUBLISHING COMPANY
See also references of EP 3572418A4
YI, C. ET AL.: "Enhanced Oral Bioavailability of a Sterol-loaded Microemulsion Formulation of Flammulina Velutipes, a Potential Antitumor Drug", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 7, no. 19, 2012, pages 5067 - 5078, XP055505870
YI, C. ET AL.: "Enhanced Oral Bioavailability and Tissue Distribution of a New Potential Anticancer Agent, Flammulina Velutipes Sterols, through Liposomal Encapsulation", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 61, no. 25, 2013, pages 5961 - 5971, XP055505873
MISHARSN, A. Y. ET AL.: "Novel Side Chain Modified A8(14)-15-ketosterols", STEROIDS, vol. 72, no. 3, 20 February 2007 (2007-02-20), pages 305 - 312, XP005896012
PETER J. BARNES: "Corticosteroids, IgE, and atopy", J CLIN INVEST., vol. 107, no. 3, 1 February 2001 (2001-02-01), pages 265 - 266
CURY MARTINS J ET AL.: "Topical tacrolimus for atopic dermatitis.", COCHRANE DATABASE SYST REV, 1 July 2015 (2015-07-01)
"Remington's Pharmaceutical Science (latest version", MACK PUBLISHING COMPANY
See also references of EP 3572418A4
Attorney, Agent or Firm:
SON, Min (KR)
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