Title:
NOVEL IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/1995/015951
Kind Code:
A1
Abstract:
A novel imidazole derivative represented by general formula (1) or (2) to be used as a selective muscarine antagonist, wherein R1 represents optionally substitued phenyl or thienyl; R2 represents cyano, hydroxy, carboxy, CONR7R8 (wherein R7 and R8 represent each independently hydrogen or lower alkyl, or R7 and R8 may form together a ring comprising an alkylene chain which may contain a heteroatom) or COOR9 (wherein R9 represents lower alkylene); R3 represents hydrogen or lower alkyl; R4, R5 and R6 represent each independently hydrogen, optionally substitued lower alkyl or cycloalkyl, or R5 and R4 may form a fused benzene ring; R10 represents lower alkyl or optionally substituted aralkyl; m represents an integer of 1 to 6; and Z represents halogen.
Inventors:
MIYACHI HIROYUKI (JP)
OKAZAKI KEI (JP)
KIYOTA HIROMI (JP)
SEGAWA MITSURU (JP)
OKAZAKI KEI (JP)
KIYOTA HIROMI (JP)
SEGAWA MITSURU (JP)
Application Number:
PCT/JP1994/002021
Publication Date:
June 15, 1995
Filing Date:
December 01, 1994
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
MIYACHI HIROYUKI (JP)
OKAZAKI KEI (JP)
KIYOTA HIROMI (JP)
SEGAWA MITSURU (JP)
MIYACHI HIROYUKI (JP)
OKAZAKI KEI (JP)
KIYOTA HIROMI (JP)
SEGAWA MITSURU (JP)
International Classes:
A61K31/415; A61K31/4184; A61P1/00; A61P11/00; A61P11/08; A61P13/02; A61P15/00; C07D233/54; C07D233/60; C07D233/61; C07D235/06; C07D235/08; C07D409/06; C07D409/14; C07D521/00; (IPC1-7): C07D233/60; C07D233/61; C07D235/08; A61K31/415
Foreign References:
| JPS6112670A | 1986-01-21 | |||
| JPS54112862A | 1979-09-04 | |||
| JPS54163573A | 1979-12-26 | |||
| JPS55162777A | 1980-12-18 | |||
| JPS5756464A | 1982-04-05 |
Other References:
See also references of EP 0733621A4
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