Title:
NOVEL IMIDAZOLIDINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/028226
Kind Code:
A1
Abstract:
A compound represented by the formula (I): [Chemical formula 1] (I) [wherein Q is a group represented by the formula; [Chemical formula 2] (X) or (Y) A is hydrogen, halogeno, -ORa, or C1-4 alkyl optionally substituted by one or more halogen atoms; E's each independently is C1-6 alkyl; m is an integer of 0-3; R2 and R3 each independently is C1-6 alkyl; X1 and X2 each independently is O or S; Y is one member selected among arylene, a divalent 5- or 6-membered monocyclic heterocyclic group, and a divalent 8- to 10-membered fused-ring heterocyclic group;and Z is -CON(-Ra)-, -CO-, -COO-, -NRa-C(=NH)NRb-, -NRa-(C=N-CN)NRb-, -N(-Ra)COO-, -C(=NH)-, -SO2-, -SO2N(-Ra)-, -SO2NR1-, -N(-Ra)CO-, -N(-Ra)CON(-Rb)-, -N(COR1)CO-, -N(-Ra)SO2-, -N(SO2R1)SO2-, -N(-Ra)-, or -N(-Ra)SO2N(-Rb)-], or a salt, prodrug, or solvate of the compound. Also provided is a medicinal composition containing the compound or the like.
Inventors:
TACHIBANA KAZUTAKA (JP)
SATO HARUHIKO (JP)
OHTA MASATERU (JP)
NAKAMURA MITSUAKI (JP)
SHIRAISHI TAKUYA (JP)
YOSHINO HITOSHI (JP)
EMURA TAKASHI (JP)
HONMA AKIE (JP)
ONUMA ETSURO (JP)
KAWATA HIROMITSU (JP)
TANIGUCHI KENJI (JP)
SATO HARUHIKO (JP)
OHTA MASATERU (JP)
NAKAMURA MITSUAKI (JP)
SHIRAISHI TAKUYA (JP)
YOSHINO HITOSHI (JP)
EMURA TAKASHI (JP)
HONMA AKIE (JP)
ONUMA ETSURO (JP)
KAWATA HIROMITSU (JP)
TANIGUCHI KENJI (JP)
Application Number:
PCT/JP2005/016664
Publication Date:
March 16, 2006
Filing Date:
September 09, 2005
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
TACHIBANA KAZUTAKA (JP)
SATO HARUHIKO (JP)
OHTA MASATERU (JP)
NAKAMURA MITSUAKI (JP)
SHIRAISHI TAKUYA (JP)
YOSHINO HITOSHI (JP)
EMURA TAKASHI (JP)
HONMA AKIE (JP)
ONUMA ETSURO (JP)
KAWATA HIROMITSU (JP)
TANIGUCHI KENJI (JP)
TACHIBANA KAZUTAKA (JP)
SATO HARUHIKO (JP)
OHTA MASATERU (JP)
NAKAMURA MITSUAKI (JP)
SHIRAISHI TAKUYA (JP)
YOSHINO HITOSHI (JP)
EMURA TAKASHI (JP)
HONMA AKIE (JP)
ONUMA ETSURO (JP)
KAWATA HIROMITSU (JP)
TANIGUCHI KENJI (JP)
International Classes:
C07D233/74; A61K31/4166; A61K31/428; A61K31/4439; A61K31/454; A61K31/496; A61P5/24; A61P5/28; A61P13/08; A61P17/00; A61P17/08; A61P17/10; A61P17/14; A61P35/00; A61P43/00; C07D211/58; C07D233/86; C07D277/82; C07D401/04; C07D417/04
Foreign References:
| JPH04308579A | 1992-10-30 | |||
| JPH0219363A | 1990-01-23 | |||
| JPS50109294A | 1975-08-28 | |||
| DE2308044A1 | 1974-08-29 | |||
| JPS4977941A | 1974-07-26 | |||
| US3686271A | 1972-08-22 | |||
| US3542849A | 1970-11-24 | |||
| US5741926A | 1998-04-21 |
Other References:
See also references of EP 1790640A4
Attorney, Agent or Firm:
Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1,
Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)
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