Title:
NOVEL MONOCLONAL ANTIBODY HAVING ANTI-INFLAMMATORY ACTION
Document Type and Number:
WIPO Patent Application WO/2019/230558
Kind Code:
A1
Abstract:
Provided is an anti-inflammatory drug that is more effective and has fewer side effects in comparison to NSAIDs or steroidal anti-inflammatory drugs. Specifically, a therapeutic agent for inflammatory conditions that contains, as an active ingredient, an anti-4-HNE antibody inhibiting 4-HNE, is recognized to ameliorate the expression of various inflammation markers for cerebral infarction or ischemia reperfusion, and to have a life saving or life prolonging effect in sepsis model animals. The anti-4-HNE antibody exhibits higher efficacy even for inflammatory conditions for which existing anti-inflammatory drugs such as conventional NSAIDs or streroidal anti-inflammatroy drugs have shown no effect.
Inventors:
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
MORIOKA YUTA (JP)
WAKE HIDENORI (JP)
TOMONO YASUKO (JP)
MORI SHUJI (JP)
MORIOKA YUTA (JP)
WAKE HIDENORI (JP)
TOMONO YASUKO (JP)
Application Number:
PCT/JP2019/020453
Publication Date:
December 05, 2019
Filing Date:
May 23, 2019
Export Citation:
Assignee:
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
SOWAKAI MEDICAL FOUND (JP)
SOWAKAI MEDICAL FOUND (JP)
International Classes:
A61K39/395; A61P29/00; C07K16/44; C12N5/12; C12N15/08; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P21/00; A61P25/00; A61P25/08; A61P31/00; A61P31/12; A61P31/16; A61P37/06; C12P21/08
Domestic Patent References:
| WO2017061354A1 | 2017-04-13 |
Foreign References:
| JPH08168394A | 1996-07-02 | |||
| JP2002181820A | 2002-06-26 | |||
| US20110039353A1 | 2011-02-17 | |||
| JP2011518874A | 2011-06-30 | |||
| JP2018105841A | 2018-07-05 |
Other References:
ADACHI, J. ET AL.: "Enhanced lipid peroxidation in tourniquetrelease mice", CLINICA CHIMICA ACTA, vol. 371, 2006, pages 79 - 84, XP027877896
MATTSON MP, EXP GERONTOL, vol. 44, no. 10, 2009, pages 625 - 633
KELLER JN ET AL., JNEUROSCI, vol. 18, no. 2, 1998, pages 687 - 697
J NEUROSCI, vol. 18, no. 2, 1998, pages 687 - 697
MATTSON MP, EXP GERONTOL, vol. 44, no. 10, 2009, pages 625 - 633
KELLER JN ET AL., JNEUROSCI, vol. 18, no. 2, 1998, pages 687 - 697
J NEUROSCI, vol. 18, no. 2, 1998, pages 687 - 697
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
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