Title:
NOVEL NITROCATECHOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/230528
Kind Code:
A1
Abstract:
Provided are a novel nitrocatechol derivative having COMT inhibitory effect and DDC inhibitory effect or a salt thereof and a medicinal composition comprising the same. A compound represented by general formula (1) or a pharmaceutically acceptable salt thereof, and a medicinal composition comprising the same.
Inventors:
KATO HIROSHIGE (JP)
INOUE TSUTOMU (JP)
NAGAYAMA SACHIHO (JP)
TOKUYAMA RYUKO (JP)
KOBASHI SEIICHI (JP)
MATSUMOTO KOJI (JP)
HOSOYA TAKUJI (JP)
INOUE TSUTOMU (JP)
NAGAYAMA SACHIHO (JP)
TOKUYAMA RYUKO (JP)
KOBASHI SEIICHI (JP)
MATSUMOTO KOJI (JP)
HOSOYA TAKUJI (JP)
Application Number:
PCT/JP2018/022310
Publication Date:
December 20, 2018
Filing Date:
June 12, 2018
Export Citation:
Assignee:
FUJIYAKUHIN CO LTD (JP)
International Classes:
C07D271/06; A61K31/41; A61K31/415; A61K31/417; A61K31/4192; A61K31/4196; A61K31/42; A61K31/421; A61K31/4245; A61K31/426; A61K31/433; A61K31/4439; A61K31/454; A61K31/501; A61P25/16; A61P43/00; C07D231/12; C07D233/64; C07D249/06; C07D249/08; C07D257/04; C07D261/04; C07D263/32; C07D271/10; C07D277/28; C07D277/56; C07D285/08; C07D401/04; C07D401/06; C07D403/04; C07D405/04; C07D409/04; C07D413/06; C07D413/08
Foreign References:
| JP2011021009A | 2011-02-03 | |||
| JPS62240649A | 1987-10-21 | |||
| JP2008308493A | 2008-12-25 | |||
| JP2009544571A | 2009-12-17 |
Other References:
KISS, L. E. ET AL.: "Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-0- methyltransferase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 8, 24 March 2010 (2010-03-24), pages 3396 - 3411, XP055563225, Retrieved from the Internet
EGOROV, M. ET AL.: "A concise formation of N- substituted 3, 4-diarylpyrroles - synthesis and cytotoxic activity", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 9, 2014, pages 1518 - 1524, XP055204836
SCHOBERT, R. ET AL.: "4-(3-Halo/amino-4, 5- dimethoxyphenyl)-5-aryloxazoles and -N- methylimidazoles That Are Cytotoxic against Combretastatin A Resistant Tumor Cells and Vascular Disrupting in a Cisplatin Resistant Germ Cell Tumor Model", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 18, 23 August 2010 (2010-08-23), pages 6595 - 6602, XP055147808
DATABASE Database REGISTRY [o] 1 November 2012 (2012-11-01), retrieved from STN Database accession no. 1402714- 31-1
EGOROV, M. ET AL.: "A concise formation of N- substituted 3, 4-diarylpyrroles - synthesis and cytotoxic activity", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 9, 2014, pages 1518 - 1524, XP055204836
SCHOBERT, R. ET AL.: "4-(3-Halo/amino-4, 5- dimethoxyphenyl)-5-aryloxazoles and -N- methylimidazoles That Are Cytotoxic against Combretastatin A Resistant Tumor Cells and Vascular Disrupting in a Cisplatin Resistant Germ Cell Tumor Model", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 18, 23 August 2010 (2010-08-23), pages 6595 - 6602, XP055147808
DATABASE Database REGISTRY [o] 1 November 2012 (2012-11-01), retrieved from STN Database accession no. 1402714- 31-1
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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