Title:
NOVEL OLIGOSACCHARIDE, MANUFACTURING INTERMEDIATE FOR NOVEL OLIGOSACCHARIDE, AND METHOD FOR MANUFACTURING THESE
Document Type and Number:
WIPO Patent Application WO/2023/074843
Kind Code:
A1
Abstract:
[Problem] The problem of the present invention is to provide: a novel oligosaccharide that can be used in order to manufacture a 2-branched glycan having an α2,6-sialic acid structure at a non-reducing end; a method for manufacturing the same; a manufacturing intermediate for the novel oligosaccharide; a method for manufacturing the intermediate; a novel oligosaccharide that is a 2-branched glycan having an α2,6-sialic acid structure at a non-reducing end; a method for manufacturing that oligosaccharide; an intermediate of that oligosaccharide; and a method for manufacturing that intermediate. [Solution] Provided are: novel oligosaccharides shown in formulas A-13 and D-13; a method for manufacturing the oligosaccharides shown in formula A-13 and formula D-13, as shown in fig. 1, fig. 3, etc.; an intermediate of those novel oligosaccharides; and a method for manufacturing the intermediate.
Inventors:
UEDA TSUYOSHI (JP)
ITOH RYUSEI (JP)
NAKAMURA TATSUYA (JP)
SUZUKI KEISUKE (JP)
NAKANE SATOSHI (JP)
YANG ZEKUN (JP)
ITOH RYUSEI (JP)
NAKAMURA TATSUYA (JP)
SUZUKI KEISUKE (JP)
NAKANE SATOSHI (JP)
YANG ZEKUN (JP)
Application Number:
PCT/JP2022/040346
Publication Date:
May 04, 2023
Filing Date:
October 28, 2022
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C08B37/00; C07H1/00; C07H15/203; C07H19/04
Domestic Patent References:
| WO2003008431A1 | 2003-01-30 |
Foreign References:
| JP2019515876A | 2019-06-13 | |||
| JP2021504439A | 2021-02-15 |
Other References:
NAKAHARA, Y. SHIBAYAMA, S. NAKAHARA, Y. OGAWA, T.: "Rationally designed syntheses of high-mannose and complex type undecasaccharides", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 280, no. 1, 4 January 1996 (1996-01-04), GB , pages 67 - 84, XP004018834, ISSN: 0008-6215, DOI: 10.1016/0008-6215(95)00262-6
OGAWA TOMOYA, MAMORU SUGIMOTO, TOORU KITAJIMA, KHALID KHAN SADOZAI, TOMOO NUKADA: "Total synthesis of a undecasaccharide: A typical carbohydrate sequence for the complex type of glycan chains of a glycoprotein", TETRAHEDRON LETTERS, vol. 27, no. 47, 1 January 1986 (1986-01-01), pages 5739 - 5742, XP093061770
KATSUNORI TANAKA, YOHEI FUJII, HIROOMI TOKIMOTO, YASUTAKA MORI, SHIN-ICHI TANAKA, GUANG-MING BAO, ERIC R.O. SIWU, AIKO NAK: "Synthesis of a Sialic Acid Containing Complex-Type N -Glycan on a Solid Support", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, HOBOKEN, USA, vol. 4, no. 4, 6 April 2009 (2009-04-06), Hoboken, USA, pages 574 - 580, XP055414595, ISSN: 1861-4728, DOI: 10.1002/asia.200800411
OGAWA TOMOYA, MAMORU SUGIMOTO, TOORU KITAJIMA, KHALID KHAN SADOZAI, TOMOO NUKADA: "Total synthesis of a undecasaccharide: A typical carbohydrate sequence for the complex type of glycan chains of a glycoprotein", TETRAHEDRON LETTERS, vol. 27, no. 47, 1 January 1986 (1986-01-01), pages 5739 - 5742, XP093061770
KATSUNORI TANAKA, YOHEI FUJII, HIROOMI TOKIMOTO, YASUTAKA MORI, SHIN-ICHI TANAKA, GUANG-MING BAO, ERIC R.O. SIWU, AIKO NAK: "Synthesis of a Sialic Acid Containing Complex-Type N -Glycan on a Solid Support", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, HOBOKEN, USA, vol. 4, no. 4, 6 April 2009 (2009-04-06), Hoboken, USA, pages 574 - 580, XP055414595, ISSN: 1861-4728, DOI: 10.1002/asia.200800411
Attorney, Agent or Firm:
KAWAGUTI & PARTNERS (JP)
Download PDF: