Title:
NOVEL OXADIAZOLE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/080765
Kind Code:
A1
Abstract:
The present invention pertains to an oxadiazole derivative and a composition containing same for preventing or treating NADPH oxidase (NOX)-related diseases. The present invention can be used to treat NADPH oxidase (NOX)-related diseases through an excellent NOX inhibitory effect.
Inventors:
BAE YUN SOO (KR)
JEONG DA UN (KR)
JEONG DA UN (KR)
Application Number:
PCT/KR2022/095004
Publication Date:
May 11, 2023
Filing Date:
January 04, 2022
Export Citation:
Assignee:
CELROS BIOTECH (KR)
International Classes:
C07D271/113; A61K31/4245; A61K31/495; A61K45/06; A61P25/28; A61P35/00; C07D413/10
Other References:
BOSHTA NADER M.; ELGAMAL ENAS A.; EL-SAYED IBRAHIM E.: "Bioactive amide andα-aminophosphonate inhibitors for methicillin-resistantStaphylococcus aureus(MRSA)", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY, SPRINGER VIENNA, VIENNA, vol. 149, no. 12, 16 October 2018 (2018-10-16), Vienna, pages 2349 - 2358, XP036634492, ISSN: 0026-9247, DOI: 10.1007/s00706-018-2303-y
SUN KEER, METZGER DENNIS W.: "Influenza Infection Suppresses NADPH Oxidase–Dependent Phagocytic Bacterial Clearance and Enhances Susceptibility to Secondary Methicillin-Resistant Staphylococcus aureus Infection", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 192, no. 7, 1 April 2014 (2014-04-01), US , pages 3301 - 3307, XP093063560, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1303049
MOCHONA BEREKET; QI XIN; EUYNNI SURESH; SIKAZWI DONALD; MATEEVA NELLY; SOLIMAN KARAM F.: "Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 26, no. 12, 21 April 2016 (2016-04-21), Amsterdam NL , pages 2847 - 2851, XP029557110, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.04.058
KAUR JATINDER; SOTO-VELASQUEZ MONICA; DING ZHONG; GHANBARPOUR AHMADREZA; LILL MARKUS A.; VAN RIJN RICHARD M.; WATTS VAL J.; FLAHER: "Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 162, 2019, AMSTERDAM, NL , pages 568 - 585, XP085568970, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.11.036
CHENG, T.J.R. ; WU, Y.T. ; YANG, S.T. ; LO, K.H. ; CHEN, S.K. ; CHEN, Y.H. ; HUANG, W.I. ; YUAN, C.H. ; GUO, C.W. ; HUANG, L.Y. ; : "High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 24, 15 December 2010 (2010-12-15), AMSTERDAM, NL, pages 8512 - 8529, XP027524846, ISSN: 0968-0896
SUN KEER, METZGER DENNIS W.: "Influenza Infection Suppresses NADPH Oxidase–Dependent Phagocytic Bacterial Clearance and Enhances Susceptibility to Secondary Methicillin-Resistant Staphylococcus aureus Infection", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 192, no. 7, 1 April 2014 (2014-04-01), US , pages 3301 - 3307, XP093063560, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1303049
MOCHONA BEREKET; QI XIN; EUYNNI SURESH; SIKAZWI DONALD; MATEEVA NELLY; SOLIMAN KARAM F.: "Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 26, no. 12, 21 April 2016 (2016-04-21), Amsterdam NL , pages 2847 - 2851, XP029557110, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.04.058
KAUR JATINDER; SOTO-VELASQUEZ MONICA; DING ZHONG; GHANBARPOUR AHMADREZA; LILL MARKUS A.; VAN RIJN RICHARD M.; WATTS VAL J.; FLAHER: "Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 162, 2019, AMSTERDAM, NL , pages 568 - 585, XP085568970, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.11.036
CHENG, T.J.R. ; WU, Y.T. ; YANG, S.T. ; LO, K.H. ; CHEN, S.K. ; CHEN, Y.H. ; HUANG, W.I. ; YUAN, C.H. ; GUO, C.W. ; HUANG, L.Y. ; : "High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 24, 15 December 2010 (2010-12-15), AMSTERDAM, NL, pages 8512 - 8529, XP027524846, ISSN: 0968-0896
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
Download PDF: