NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES

Title:

NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES

Document Type and Number:

WIPO Patent Application WO1999064050

Kind Code:

A8

Abstract:

This invention relates to novel multibinding compounds that bind to potassium (K<+>) channels and modulate their activity. The compounds of this invention comprise 2-10 K<+> channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of K<+> channel. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to the K<+> channel. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by K<+> channels. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.

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Inventors:

JACOBSEN JOHN R (US)
EASTMAN DONNA (US)
GRIFFIN JOHN H (US)

Application Number:

PCT/US1999/012777

Publication Date:

February 24, 2000

Filing Date:

June 07, 1999

Export Citation:

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Assignee:

ADVANCED MEDICINE INC (US)
JACOBSEN JOHN R (US)
EASTMAN DONNA (US)
GRIFFIN JOHN H (US)

International Classes:

G01N33/50; A61K9/06; A61K31/18; A61K31/343; A61K31/395; A61K31/407; A61K31/4178; A61K31/4427; A61K31/443; A61K31/4545; A61K45/00; A61K47/48; A61P9/00; A61P43/00; C07C311/08; C07C311/10; C07C311/12; C07C311/22; C07C311/30; C07D257/02; C07D307/80; C07D401/06; C07D405/12; C07D487/04; C07D487/08; C07K5/09; C07K5/11; C07K7/06; C07K7/08; G01N33/15; G01N33/566; G01N33/68; (IPC1-7): A61K38/00; A61K39/00; A61K39/395; A61K39/44; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566

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