NOVEL SUBSTITUTED MACROHETEROCYCLIC COMPOUNDS AND USE THEREOF

Title:

NOVEL SUBSTITUTED MACROHETEROCYCLIC COMPOUNDS AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/179600

Kind Code:

A1

Abstract:

Disclosed in the present invention are novel substituted macroheterocyclic compounds, which can be used as inhibitors for targets such as ALK mutations, or ALK mutation related signaling pathways, for example NTRKs, ROS1, BRAF, c-MET, EGFR/HER2, KRAS/MEK, PIK3CA, FDFR, DDR2 and/or VEGFR, PI3K, CDKs and PARP. Specifically disclosed are compounds represented by formula (I), or pharmaceutically acceptable salts, solvates, hydrates, isotope substitutes, or isomers thereof. The compounds having structures of the formula (I) have an inhibition effect on targets such as ALK mutations, NTRKs and ROS1, and particularly have a strong inhibition effect on ALK composite mutant protein (such as L1196M/G1202R), and therefore can be used for preparing drugs or molecular probes used for preventing or treating diseases (such as cancer and immune diseases) that are related to ALK mutations (especially composite mutations), and NTRKs, ROS1, BRAF, c-MET, EGFR/HER2, KRAS/MEK, PIK3CA, FDFR, DDR2 and/or VEGFR, PI3K, CDKs and PARP signaling pathways.

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Inventors:

ZHANG LONG (CN)
NIU ZHANGMING (CN)

Application Number:

PCT/CN2023/082758

Publication Date:

September 28, 2023

Filing Date:

March 21, 2023

Export Citation:

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Assignee:

MINDRANK AI LTD (CN)

International Classes:

C07D491/18; A61K31/437; A61K31/439; A61K31/5383; A61P35/00; C07D491/12; C07D497/18; C07D498/12; C07D498/18; C07D498/22

Domestic Patent References:

WO2021226269A1	2021-11-11
WO2021226208A2	2021-11-11
WO2021027503A1	2021-02-18
WO2020257165A1	2020-12-24
WO2019126122A1	2019-06-27

Foreign References:

CN104513253A

2015-04-15

Attorney, Agent or Firm:

BEIJING ORIGINTELLIGENCE IP LAW FIRM et al. (CN)

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