Title:
NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2011/024468
Kind Code:
A1
Abstract:
Disclosed is a novel compound which has both angiotensin II receptor antagonist activity and PPARγ activating activity, and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, kidney diseases, arteriosclerosis, inflammatory diseases, type 2 diabetes, diabetic complication, insulin resistant syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. Also disclosed is a pharmaceutical composition which contains the novel compound.
Specifically disclosed are: a sulfonamide derivative represented by general formula (I), a salt thereof, or a solvate of the derivative or salt; and a pharmaceutical composition which contains the sulfonamide derivative, a salt thereof, or a solvate of the derivative or salt.
(In the formula, R1 represents a C1-6 alkyl group; R2 and R3 each represents a C1-6 alkyl group or the like; and R4 represents a hydrogen atom, a C1-6 alkyl group, a C1-6 alkanoyl group or a C3-8 cycloalkylcarbonyl group.)
Inventors:
MIURA TORU (JP)
ONOGI KAZUHIRO (JP)
GOMI NORIAKI (JP)
ARAKI TAKAAKI (JP)
TAGASHIRA JUNYA (JP)
SEKIMOTO RYOHEI (JP)
ISHIDA RIE (JP)
AOKI HITOMI (JP)
OHGIYA TADAAKI (JP)
ONOGI KAZUHIRO (JP)
GOMI NORIAKI (JP)
ARAKI TAKAAKI (JP)
TAGASHIRA JUNYA (JP)
SEKIMOTO RYOHEI (JP)
ISHIDA RIE (JP)
AOKI HITOMI (JP)
OHGIYA TADAAKI (JP)
Application Number:
PCT/JP2010/005286
Publication Date:
March 03, 2011
Filing Date:
August 27, 2010
Export Citation:
Assignee:
KOWA CO (JP)
MIURA TORU (JP)
ONOGI KAZUHIRO (JP)
GOMI NORIAKI (JP)
ARAKI TAKAAKI (JP)
TAGASHIRA JUNYA (JP)
SEKIMOTO RYOHEI (JP)
ISHIDA RIE (JP)
AOKI HITOMI (JP)
OHGIYA TADAAKI (JP)
MIURA TORU (JP)
ONOGI KAZUHIRO (JP)
GOMI NORIAKI (JP)
ARAKI TAKAAKI (JP)
TAGASHIRA JUNYA (JP)
SEKIMOTO RYOHEI (JP)
ISHIDA RIE (JP)
AOKI HITOMI (JP)
OHGIYA TADAAKI (JP)
International Classes:
C07D239/36; A61K31/513; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/10; A61P43/00
Domestic Patent References:
| WO1991015209A1 | 1991-10-17 | |||
| WO2008143262A1 | 2008-11-27 | |||
| WO2008062905A2 | 2008-05-29 | |||
| WO2008062905A2 | 2008-05-29 | |||
| WO2008084303A1 | 2008-07-17 | |||
| WO2008096820A1 | 2008-08-14 | |||
| WO2008096829A1 | 2008-08-14 | |||
| WO2008143262A1 | 2008-11-27 |
Foreign References:
| JPH08208632A | 1996-08-13 | |||
| JPH0920764A | 1997-01-21 | |||
| US5166206A | 1992-11-24 | |||
| EP0561664A1 | 1993-09-22 |
Other References:
See also references of EP 2471782A4
AMER, J. HYPERTENSION, vol. 18, 2005, pages 720
CURRENT HYPERTENSION REPORT, vol. 10, 2008, pages 261
DIABETES CARE, vol. 30, 2007, pages 1581
KIDNEY INT., vol. 70, 2006, pages 1223
CIRCULATION, vol. 108, 2003, pages 2941
BEST PRACT. RES. CLIN. ENDOCRINOL. METAB., vol. 21, no. 4, 2007, pages 687
DIAB. VASC. DIS. RES., vol. 1, no. 2, 2004, pages 76
DIAB. VASC. DIS. RES., vol. 2, no. 2, 2005, pages 61
J. CLIN. INVEST., vol. 116, no. 3, 2006, pages 581
FASEB J., vol. 20, no. 8, 2006, pages 1203
HYPERTENSION, vol. 43, 2004, pages 993
CIRCULATION, vol. 109, 2004, pages 2054
PROGRESS IN MEDICINE, vol. 5, 1985, pages 2157 - 2161
"Molecular Designs", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Drugs", pages: 163 - 198
"Protecting groups in Organic Synthesis", JOHN WILEY & SONS, INC.
AMER, J. HYPERTENSION, vol. 18, 2005, pages 720
CURRENT HYPERTENSION REPORT, vol. 10, 2008, pages 261
DIABETES CARE, vol. 30, 2007, pages 1581
KIDNEY INT., vol. 70, 2006, pages 1223
CIRCULATION, vol. 108, 2003, pages 2941
BEST PRACT. RES. CLIN. ENDOCRINOL. METAB., vol. 21, no. 4, 2007, pages 687
DIAB. VASC. DIS. RES., vol. 1, no. 2, 2004, pages 76
DIAB. VASC. DIS. RES., vol. 2, no. 2, 2005, pages 61
J. CLIN. INVEST., vol. 116, no. 3, 2006, pages 581
FASEB J., vol. 20, no. 8, 2006, pages 1203
HYPERTENSION, vol. 43, 2004, pages 993
CIRCULATION, vol. 109, 2004, pages 2054
PROGRESS IN MEDICINE, vol. 5, 1985, pages 2157 - 2161
"Molecular Designs", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Drugs", pages: 163 - 198
"Protecting groups in Organic Synthesis", JOHN WILEY & SONS, INC.
Attorney, Agent or Firm:
SAEKI, NORIO (JP)
Norio Saeki (JP)
Norio Saeki (JP)
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