Title:
NOVEL THERAPEUTIC TARGET FUSION GENE IN BILIARY TRACT CANCER
Document Type and Number:
WIPO Patent Application WO/2016/084883
Kind Code:
A1
Abstract:
[Problem] To identify a mutation which can serve as a target for a molecular therapy for cancer such as biliary tract cancer and which can also serve as an indicator for predicting the efficacy of a therapy with a medicine; to provide a means for detecting the mutation; to provide a means for identifying a cancer patient or a subject at risk for cancer on whom a medicine targeting a gene having the mutation or a protein encoded by the gene can exert a therapeutic effect, on the basis of the mutation; and others. [Solution] A method for detecting gene fusion that is a cancer driver mutation, said method comprising a step of detecting a fusion polynucleotide selected from a FGFR2-TXLNA fusion polynucleotide, a FGFR2-KCTD1 fusion polynucleotide and a FGFR2-BICC1 type 2 fusion polynucleotide or a polypeptide encoded by the fusion polynucleotide in a sample isolated from a subject with cancer.
Inventors:
SHIBATA TATSUHIRO (JP)
ARAI YASUHITO (JP)
ARAI YASUHITO (JP)
Application Number:
PCT/JP2015/083186
Publication Date:
June 02, 2016
Filing Date:
November 26, 2015
Export Citation:
Assignee:
NAT CANCER CT (JP)
LSIP LLC (JP)
LSIP LLC (JP)
International Classes:
C12Q1/68; A61K31/404; A61K31/496; A61K31/506; A61K31/519; A61K31/53; A61K45/00; A61P35/00; C07K14/47; C07K14/705; C07K19/00; C12N9/12; C12N15/09; G01N33/15; G01N33/50; G01N33/574
Domestic Patent References:
| WO2014071419A2 | 2014-05-08 | |||
| WO2014007369A1 | 2014-01-09 | |||
| WO2014145751A2 | 2014-09-18 |
Other References:
YASUHITO ARAI: "Fusion gene discovery for target therapy in solid tumor", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 249, no. 10, 7 June 2014 (2014-06-07), pages 1107 - 1112, ISSN: 0039-2359
TANDO GAN DE KOKUNAI HATSU BUNSHI HYOTEKI-YAKU KAIHATSU NI MUKETA RINSHO KENKYU KAISHI, 6 June 2014 (2014-06-06)
CHIGUSA MORIZANE ET AL.: "Tando Gan ni Taisuru Chiryo Kaihatsu o Nento ni Oita FGFR2 Yugo Idenshi no Screening Kenkyu", JOURNAL OF JAPAN BILIARY ASSOCIATION, vol. 28, no. 3, 31 August 2014 (2014-08-31), ISSN: 0914-0077
TANDO GAN DE KOKUNAI HATSU BUNSHI HYOTEKI-YAKU KAIHATSU NI MUKETA RINSHO KENKYU KAISHI, 6 June 2014 (2014-06-06)
CHIGUSA MORIZANE ET AL.: "Tando Gan ni Taisuru Chiryo Kaihatsu o Nento ni Oita FGFR2 Yugo Idenshi no Screening Kenkyu", JOURNAL OF JAPAN BILIARY ASSOCIATION, vol. 28, no. 3, 31 August 2014 (2014-08-31), ISSN: 0914-0077
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
Download PDF: