Title:
A NOVEL THIOL REDUCTANT, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041545
Kind Code:
A1
Abstract:
The present disclosure relates to a novel thiol reductant having the formula (I), the preparation and the use in antibody modification.
Inventors:
WU LILI (CN)
JI AO (CN)
HE WENXU (CN)
WANG YICHENG (CN)
SHI YU (CN)
RAN YAJUN (CN)
JI AO (CN)
HE WENXU (CN)
WANG YICHENG (CN)
SHI YU (CN)
RAN YAJUN (CN)
Application Number:
PCT/CN2023/114320
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
Assignee:
SUZHOU BIOREINNO BIOTECHNOLOGY LTD COMPANY (CN)
International Classes:
C07F9/50; A61K31/662; A61K31/664; A61P35/00; C07K16/00; C07K16/28; C07K16/32
Domestic Patent References:
| WO2022078524A2 | 2022-04-21 |
Foreign References:
| US4315867A | 1982-02-16 | |||
| CN107922477A | 2018-04-17 |
Other References:
CLINE DANIEL J., REDDING SARAH E., BROHAWN STEPHEN G., PSATHAS JAMES N., SCHNEIDER JOEL P., THORPE COLIN: "New Water-Soluble Phosphines as Reductants of Peptide and Protein Disulfide Bonds: Reactivity and Membrane Permeability", BIOCHEMISTRY, vol. 43, no. 48, 1 December 2004 (2004-12-01), pages 15195 - 15203, XP093144381, ISSN: 0006-2960, DOI: 10.1021/bi048329a
HE PEI-YANG, CHEN HUAI, HU HONG-GUO, HU JIN-JIAN, LIM YEH-JUN, LI YAN-MEI: "Late-stage peptide and protein modifications through phospha-Michael addition reaction", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 83, 20 October 2020 (2020-10-20), UK , pages 12632 - 12635, XP093144382, ISSN: 1359-7345, DOI: 10.1039/D0CC04969G
HE PEI-YANG, CHEN HUAI, HU HONG-GUO, HU JIN-JIAN, LIM YEH-JUN, LI YAN-MEI: "Late-stage peptide and protein modifications through phospha-Michael addition reaction", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 83, 20 October 2020 (2020-10-20), UK , pages 12632 - 12635, XP093144382, ISSN: 1359-7345, DOI: 10.1039/D0CC04969G
Attorney, Agent or Firm:
BEIJING HAN KUN LAW OFFICES (CN)
Download PDF:
Previous Patent: A METHOD OF PREPARING AN ANTIBODY WITH SITE-SPECIFIC MODIFICATIONS
Next Patent: CHIP, CHIP ASSEMBLY, AND IMAGING MATERIAL CARTRIDGE
Next Patent: CHIP, CHIP ASSEMBLY, AND IMAGING MATERIAL CARTRIDGE