Title:
NOVEL USE OF GENE WHOSE EXPRESSION IS INCREASED IN HYPERPLASTIC PANCREATIC ISLET
Document Type and Number:
WIPO Patent Application WO/2007/125621
Kind Code:
A1
Abstract:
It is intended to provide a pharmaceutical composition for treating and/or preventing
a disease requiring the promotion of cell growth comprising NM_025363 or an analogue
thereof or a product thereof, a pharmaceutical composition for treating and/or
preventing a disease requiring the inhibition of cell growth comprising a substance
inhibiting the expression and/or function of NM_025363 or an analogue thereof
or a product thereof, a screening method for such substances promoting and inhibiting
the cell growth, etc.
Inventors:
BABA AKEMICHI (JP)
SHINTANI NORIHITO (JP)
HASHIMOTO HITOSHI (JP)
SUGIMOTO YUKIHIKO (JP)
SHINTANI NORIHITO (JP)
HASHIMOTO HITOSHI (JP)
SUGIMOTO YUKIHIKO (JP)
Application Number:
PCT/JP2006/321714
Publication Date:
November 08, 2007
Filing Date:
October 31, 2006
Export Citation:
Assignee:
UNIV OSAKA (JP)
BABA AKEMICHI (JP)
SHINTANI NORIHITO (JP)
HASHIMOTO HITOSHI (JP)
SUGIMOTO YUKIHIKO (JP)
BABA AKEMICHI (JP)
SHINTANI NORIHITO (JP)
HASHIMOTO HITOSHI (JP)
SUGIMOTO YUKIHIKO (JP)
International Classes:
A61K48/00; A61K38/00; A61K45/00; A61P1/18; A61P3/10; A61P35/00; A61P43/00; C12N15/00; C12Q1/02; C12Q1/68
Domestic Patent References:
| WO2002059149A2 | 2002-08-01 | |||
| WO2000052165A2 | 2000-09-08 |
Other References:
HAMAGAMI K. ET AL.: "Tonyobyo Byotaika ni Okeru Suishimaka Keiseiji ni Hatsugen Josho suru Idenshi no Kino Kaiseki", DAI 108 KAI THE JAPANESE PHARMACOLOGICAL SOCIETY KINKI BUKAI PROGRAM YOSHISHU, no. C-6, 2005, pages 65, XP003019156
WILLIAMS S.S. ET AL.: "Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure", PHYSIOL. GENOMICS, vol. 19, no. 2, 2004, pages 184 - 197, XP003019157
TRAN V.V. ET AL.: "Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy", DIABETES, vol. 52, no. 6, 2003, pages 1423 - 1432, XP003019158
SONG K. ET AL.: "Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance", MOL. ENDOCRINOL., vol. 19, no. 2, 2005, pages 504 - 515, XP003019159
WILLIAMS S.S. ET AL.: "Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure", PHYSIOL. GENOMICS, vol. 19, no. 2, 2004, pages 184 - 197, XP003019157
TRAN V.V. ET AL.: "Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy", DIABETES, vol. 52, no. 6, 2003, pages 1423 - 1432, XP003019158
SONG K. ET AL.: "Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance", MOL. ENDOCRINOL., vol. 19, no. 2, 2005, pages 504 - 515, XP003019159
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building3-7, Shiromi 1-chome,Chuo-ku, Osaka-shi, Osaka 01, JP)
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