NOVEL USE OF SULFORAPHANE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Title:

NOVEL USE OF SULFORAPHANE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Document Type and Number:

WIPO Patent Application WO/2021/115100

Kind Code:

A1

Abstract:

Provided are new use of sulforaphane for preparing a TFEB activator and for preparing drugs in the treatment and/or prevention of lysosomal storage diseases, and a pharmaceutical composition comprising same. It is confirmed that sulforaphane can promote the biosynthesis of lysosome and increase the activity of the lysosome by activating TFEB, so as to degrade storages in the lysosome. As sulforaphane has the described functions, it can be used for preparing drugs for treating and/or preventing lysosomal storage diseases.

More Like This:

WO/2020/046153	CONJUGATES OF SELENIUM AND ISOTHIOCYANATE NANOPARTICLES FOR USE IN THE TREATMENT OF TUMORS
WO/2010/140271	SUBSTANCE HAVING RELAXING ACTIVITY, CONCENTRATION-ENHANCING ACTIVITY AND ANTI-STRESS ACTIVITY
WO/2013/015666	METHOD OF EXTRACTING SULFORAPHANE BY MEANS OF A LACTIC FERMENTATION TREATMENT IN CRUCIFEROUS PLANTS

Inventors:

LI DAN (CN)
XU HAOXIN (US)

Application Number:

PCT/CN2020/130447

Publication Date:

June 17, 2021

Filing Date:

November 20, 2020

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV ZHEJIANG TECHNOLOGY (CN)
UNIV MICHIGAN (US)

International Classes:

A61K31/26; A61P3/00; A61P35/00; A61P39/06

Domestic Patent References:

WO2020167822A2	2020-08-20
WO2012162535A1	2012-11-29

Foreign References:

CN111012773A	2020-04-17
JP2018131429A	2018-08-23
CN104640573A	2015-05-20
CN103079545A	2013-05-01
CN101120948A	2008-02-13

Other References:

MEANEY STEVE, GRAY STEVEN G: "Epigenetic regulation of cholesterol homeostasis", FRONTIERS IN GENETICS, vol. 5, 24 September 2014 (2014-09-24), pages 1 - 10, XP055820301, DOI: 10.3389/fgene.2014.00311

Attorney, Agent or Firm:

PATENTSINO IP FIRM (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: MULTISPECTRAL ULTRAVIOLET LIGHT SENSITIVITY MEASUREMENT SYSTEM AND METHOD

Next Patent: MEDIUM-HIGH VOLTAGE BIDIRECTIONAL ALL-SOLID-STATE DIRECT-CURRENT CIRCUIT BREAKER AND HIGH-POTENTIAL ...