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Title:
NUCLEIC ACID-CONTAINING LIPID NANO-PARTICLE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/131770
Kind Code:
A1
Abstract:
The present invention provides a lipid nano-particle containing the following components (a) to (c): (a) a nucleic acid encoding a chimeric antigen receptor (CAR) or an exogenous T cell receptor (TCR); (b) a cationic lipid; and (c) a non-cationic lipid. The present invention also provides: a CAR-expressing or exogenous-TCR-expressing immunocyte produced by introducing the lipid nano-particle into a T cell in vivo or ex vivo; and a means for the in vivo or ex vivo treatment of diseases including cancer using the immunocyte.

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Inventors:
KUWAE SHINOBU (JP)
MATSUMOTO SATORU (JP)
Application Number:
PCT/JP2018/047872
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61K48/00; A61K9/127; A61K31/7105; A61K31/711; A61K47/18; A61K47/24; A61K47/28; A61K47/34; A61K47/42; A61P35/00; A61P37/04; C07K14/725; C07K16/28; C12N5/10; C12N15/12
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See also references of EP 3733211A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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