NOVEL ANTI-PAD4 ANTIBODY - UNIV NAGOYA CITY PUBLIC UNIV CORP

Title:

NOVEL ANTI-PAD4 ANTIBODY

Document Type and Number:

WIPO Patent Application WO/2019/131769

Kind Code:

A1

Abstract:

An anti-PAD4 antibody that binds to active PAD4 or an anti-PAD4 antibody that inhibits the function of active PAD4 is achieved. An anti-PAD4 antibody is used which binds to active PAD4. Or, an anti-PAD4 antibody which binds specifically to a peptide formed from the amino acid sequence represented by sequence number 1, or an anti-PAD4 antibody which binds specifically to positions 633-644 of human PAD4 is used. This anti-PAD4 antibody optionally inhibits the citrullination activity of PAD4.

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Inventors:

KANAZAWA SATOSHI (JP)
SATO MAMORU (JP)
YAMADA MICHIYUKI (JP)

Application Number:

PCT/JP2018/047871

Publication Date:

July 04, 2019

Filing Date:

December 26, 2018

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Assignee:

UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)

International Classes:

C12N15/13; C07K7/08; C07K16/40; C12N15/67; C12P21/08; G01N33/53; C12N5/10

Domestic Patent References:

WO2012026309A1	2012-03-01
WO2016143753A1	2016-09-15
WO2010005293A1	2010-01-14

Foreign References:

JP2005137361A	2005-06-02
JP2007524583A	2007-08-30

Other References:

ARITA, KYOUHEI ET AL.: "Structural Biology of Peptidylarginine Deiminase 4 (PAD4) Associated with Rheumatoid Arthritis", SPRING-8/SACLA INFORMATION, vol. 11, no. 5, pages 319 - 328
ARITA, KYOUHEI ET AL.: "Structural basis for Ca2+- induced activation of human PAD4", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 11, no. 8, 2004, pages 777 - 783, XP002355831

Attorney, Agent or Firm:

SK INTELLECTUAL PROPERTY LAW FIRM et al. (JP)

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