NUCLEIC ACID HAVING CARRIER PEPTIDE LINKED THERETO

Title:

NUCLEIC ACID HAVING CARRIER PEPTIDE LINKED THERETO

Document Type and Number:

WIPO Patent Application WO/2023/171820

Kind Code:

A1

Abstract:

In the present description, there are provided; a nucleic acid having a carrier peptide linked thereto, or a pharmaceutically acceptable salt of the nucleic acid, or a hydrate of the nucleic acid or the pharmaceutically acceptable salt; and others. The nucleic acid having a carrier peptide linked thereto or the pharmaceutically acceptable salt of the nucleic acid or the hydrate of the nucleic acid or the pharmaceutically acceptable salt comprises: a nucleic acid capable of regulating the splicing of pre-mRNA or inhibiting the function of targeted RNA or a target region in the RNA or a pharmaceutically acceptable salt of the nucleic acid or a hydrate of the nucleic acid or the pharmaceutically acceptable salt; and a carrier peptide that is linked to the nucleic acid, the pharmaceutically acceptable salt of the nucleic acid or the hydrate of the nucleic acid or the pharmaceutically acceptable salt and comprises the amino acid sequence represented by the formula KKRTLRKSNRKKR (SEQ ID NO:1) or an amino acid sequence having such a structure that one or two amino acid residues in SEQ ID NO:1 are added, deleted or substituted (provided that an amino acid sequence in which both of amino acid residues located at position-8 and position-9 from the N-terminal of SEQ ID NO:1 are substituted is excluded). In the nucleic acid having a carrier peptide linked thereto, or a pharmaceutically acceptable salt of the nucleic acid, or a hydrate of the nucleic acid or the pharmaceutically acceptable salt, the nucleic acid is selected from the group consisting of an antisense oligomer, siRNA and shRNA.

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Inventors:

SUGIYAMA HIROYUKI (JP)
NAKAMURA TAKAHIRO (JP)
NOGATA MASAKI (JP)
KOMIYAMA KEINA (JP)
KAWANO TAKAO (JP)
FUJIWARA MIKIYA (JP)
BAILEYKOBAYASHI NAHOKO (JP)
YOSHIDA TETSUHIKO (JP)

Application Number:

PCT/JP2023/009470

Publication Date:

September 14, 2023

Filing Date:

March 10, 2023

Export Citation:

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Assignee:

NIPPON SHINYAKU CO LTD (JP)

International Classes:

C12N15/113; A61K9/127; A61K31/7105; A61K31/713; A61K31/80; A61K47/64; A61K48/00; A61P21/04; C07K7/08; C12N15/87

Domestic Patent References:

WO2011013700A1	2011-02-03
WO2013100190A1	2013-07-04
WO2012029986A1	2012-03-08
WO2021125311A1	2021-06-24

Foreign References:

JP2022014707A

2022-01-20

Other References:

GOYAL PANKAJ , PANDEY DHARMENDRA, SIESS WOLFGANG: "Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 281, no. 35, 1 September 2006 (2006-09-01), US , pages 25223 - 25230, XP002622536, ISSN: 0021-9258, DOI: 10.1074/JBC.M603399200

Attorney, Agent or Firm:

KOBAYASHI Hiroshi et al. (JP)

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