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Title:
NUCLEIC ACID MOLECULES INSERTED EXPRESSION REGULATION SEQUENCES, EXPRESSION VECTOR COMPRISING NUCLEIC ACID MOLECLUES AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/209079
Kind Code:
A1
Abstract:
A nucleic acid molecule including at least one expression control sequence having an Internal Ribosomal Entry Site (IRES) sequence, at least one coding region, and optionally multiple adenosines or thymidines upstream of the at least one expression control sequence is disclosed as an expression system. Besides, a recombinant expression vector including the nucleic acid molecule and pharmaceutical or medicinal use of the nucleic acid molecule are disclosed.

Inventors:
NAM, Jae Hwan (509-703, 114 Gangchon-ro,Ilsandong-gu,Goyang-si, Gyeonggi-do, 10419, KR)
PARK, Hyo Jung (111-501, 1430 Nambusunhwan-ro,Gwanak-gu, Seoul, 08770, KR)
KO, Hae Li (#302, 8-11 Yangji-ro 184beon-gil,Bucheon-si, Gyeonggi-do, 14784, KR)
KIM, Hun (6114-2903, 76 Central town-ro,,Yeongtong-gu,Suwon-si, Gyeonggi-do, 16505, KR)
KWAK, Hae Won (109-1202, 21 Dapsimni-ro 56-gil,Dongdaemun-gu, Seoul, 02613, KR)
Application Number:
KR2019/005099
Publication Date:
October 31, 2019
Filing Date:
April 26, 2019
Export Citation:
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Assignee:
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION (222 Banpo-daero, Seocho-gu, Seoul, 06591, KR)
International Classes:
C12N15/67; A61K39/12; A61K48/00
Domestic Patent References:
WO2003031630A12003-04-17
WO2004018630A22004-03-04
Foreign References:
KR20190061114A2019-06-05
Other References:
CHARBONNEAU, J. ET AL.: "The 5' UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1 enzymes", RNA, vol. 18, no. 3, 27 January 2012 (2012-01-27), pages 519 - 529, XP055649141
LO, H. L. ET AL.: "Development of an RNA Expression Platform Controlled by Viral Internal Ribosome Entry Sites", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 29, no. 1, 28 November 2018 (2018-11-28) - 28 January 2019 (2019-01-28), pages 127 - 140, XP055649150
Attorney, Agent or Firm:
SA, Kwang Young (5th Floor, 147 Dogok-roGangnam-gu, Seoul, 06255, KR)
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